U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula 2C2H3O2.Ni
Molecular Weight 176.7814
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NICKEL ACETATE

SMILES

[Ni++].CC([O-])=O.CC([O-])=O

InChI

InChIKey=AIYYMMQIMJOTBM-UHFFFAOYSA-L
InChI=1S/2C2H4O2.Ni/c2*1-2(3)4;/h2*1H3,(H,3,4);/q;;+2/p-2

HIDE SMILES / InChI
Ni acetate is a water soluble salt of Ni, which leads to skin irritation, in particular to allergic contact dermatitis. May cause cancer according to animal studies. Symptoms of overexposure to nickel can cause sensitization, dermatitis, allergic asthma and pneumonitis.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Inhibition by magnesium and calcium acetates of lead subacetate- and nickel acetate-induced lung tumors in strain A mice.
1984 Apr
Initiation by nickel acetate and promotion by sodium barbital of renal cortical epithelial tumors in male F344 rats.
1990 Apr
Patents

Sample Use Guides

epithelial tumors in rats: Soluble nickel(II) ion, given to male F344/NCr rats as a single i.p. injection of nickel(II) acetate tetrahydrate at a dose of 90 mumols/kg body weight at 5 weeks of age, proved an effective initiator of renal cortical epithelial tumors
Route of Administration: Intraperitoneal
Human stratum corneum (SC) was prepared by trypsinization of dermatomed cadaver leg skin. The diffusion system included diffusion cells with a spiral line. Aqueous solutions of nickel salts (Ni(NO3)2, NiSO4, NiCl2 and Ni(-OOCCH3)2 at 1% Ni2+ concentration) were used as the donor solution (400 microL/cell). The receptor fluid, pure water, was collected up to 96 h after application of the donor solutions. Nickel concentrations in the donor and receptor fluid, as well as in the SC, were analysed using inductively coupled plasma mass spectrometry (ICP-MS) with a confidence limit of 0.5 ppb. Based on the total recovery of nickel from the experiments, about 98% of the dose remained in the donor solution, whereas 1% or less was retained in SC and less than 1% was found in the receptor fluid. Following an early surge, nickel permeates slowly across SC. The steady-state permeability coefficients of nickel were calculated from the flux data (approximately 5.2-8.5 x 10(-7) cm/h) with no significant difference among the salts. The results concur in principle with earlier studies conducted using the full-thickness human skin in vitro, and suggest that in vivo nickel ions may permeate simultaneously by routes of diffusion such as the shunt pathway, apart from slow transcellular/intercellular diffusion alone.
Name Type Language
NICKEL ACETATE
HSDB   MI  
Systematic Name English
NICKEL(2+) ACETATE
Systematic Name English
NICKEL ACETATE [MI]
Common Name English
NICKEL(II) ACETATE
Systematic Name English
ACETIC ACID, NICKEL(2+) SALT (2:1)
Common Name English
NICKEL ACETATE ANHYDROUS
Common Name English
NICKEL ACETATE [HSDB]
Common Name English
NICKEL DIACETATE
Systematic Name English
NSC-112210
Code English
NICKELOUS ACETATE
Common Name English
ACETIC ACID, NICKEL(2+) SALT
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C44407
Created by admin on Fri Dec 15 19:09:27 GMT 2023 , Edited by admin on Fri Dec 15 19:09:27 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C45867
Created by admin on Fri Dec 15 19:09:27 GMT 2023 , Edited by admin on Fri Dec 15 19:09:27 GMT 2023
PRIMARY
CAS
14998-37-9
Created by admin on Fri Dec 15 19:09:26 GMT 2023 , Edited by admin on Fri Dec 15 19:09:26 GMT 2023
ALTERNATIVE
ECHA (EC/EINECS)
239-086-1
Created by admin on Fri Dec 15 19:09:26 GMT 2023 , Edited by admin on Fri Dec 15 19:09:26 GMT 2023
ALTERNATIVE
EPA CompTox
DTXSID7020926
Created by admin on Fri Dec 15 19:09:26 GMT 2023 , Edited by admin on Fri Dec 15 19:09:26 GMT 2023
PRIMARY
NSC
112210
Created by admin on Fri Dec 15 19:09:27 GMT 2023 , Edited by admin on Fri Dec 15 19:09:27 GMT 2023
PRIMARY
MERCK INDEX
m7854
Created by admin on Fri Dec 15 19:09:26 GMT 2023 , Edited by admin on Fri Dec 15 19:09:26 GMT 2023
PRIMARY Merck Index
FDA UNII
99QP4ELX96
Created by admin on Fri Dec 15 19:09:26 GMT 2023 , Edited by admin on Fri Dec 15 19:09:26 GMT 2023
PRIMARY
RXCUI
1313176
Created by admin on Fri Dec 15 19:09:27 GMT 2023 , Edited by admin on Fri Dec 15 19:09:27 GMT 2023
PRIMARY RxNorm
PUBCHEM
9756
Created by admin on Fri Dec 15 19:09:27 GMT 2023 , Edited by admin on Fri Dec 15 19:09:27 GMT 2023
PRIMARY
CAS
373-02-4
Created by admin on Fri Dec 15 19:09:26 GMT 2023 , Edited by admin on Fri Dec 15 19:09:26 GMT 2023
PRIMARY
DAILYMED
99QP4ELX96
Created by admin on Fri Dec 15 19:09:26 GMT 2023 , Edited by admin on Fri Dec 15 19:09:26 GMT 2023
PRIMARY
HSDB
1029
Created by admin on Fri Dec 15 19:09:26 GMT 2023 , Edited by admin on Fri Dec 15 19:09:26 GMT 2023
PRIMARY
ECHA (EC/EINECS)
206-761-7
Created by admin on Fri Dec 15 19:09:26 GMT 2023 , Edited by admin on Fri Dec 15 19:09:26 GMT 2023
PRIMARY
WIKIPEDIA
NICKEL(II) ACETATE
Created by admin on Fri Dec 15 19:09:27 GMT 2023 , Edited by admin on Fri Dec 15 19:09:27 GMT 2023
PRIMARY