U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C25H34N2O8
Molecular Weight 490.5461
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of NILUDIPINE

SMILES

CCCOCCOC(=O)C1=C(C)NC(C)=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCOCCC

InChI

InChIKey=VZWXXKDFACOXNT-UHFFFAOYSA-N
InChI=1S/C25H34N2O8/c1-5-10-32-12-14-34-24(28)21-17(3)26-18(4)22(25(29)35-15-13-33-11-6-2)23(21)19-8-7-9-20(16-19)27(30)31/h7-9,16,23,26H,5-6,10-15H2,1-4H3

HIDE SMILES / InChI
Niludipine (Bay-a-7168) is a potent calcium antagonistic coronary vasodilator with less cardiodepressant effect than nifedipine. Niludipine is a safe antianginal Ca2+-antagonist with broad effectiveness for various types of angina pectoris. Niludipine is clinically useful as coronary vasodilator and hypotensive agent.

Approval Year

PubMed

PubMed

TitleDatePubMed
Antihypertensive effect of Niludipine (Bay a 7168) on conscious renal-hypertensive dogs.
1979
Comparative coronary vasodilatory effects of nifedipine and niludipine.
1981
Effects of new calcium channel blocker of niludipine on the coronary hemodynamics, diastolic properties, and metabolic responses to tachycardia stress in patients with coronary disease.
1982
Effects of Ca antagonists, nifedipine, niludipine and verapamil, on endocrine function of the pancreas.
1983 Jun
Acute and chronic hypotensive effects of nifedipine and niludipine in hypertensive patients with chronic renal failure.
1984
Patents

Patents

Sample Use Guides

Angina pectoris: Oral administration of from 60--120 mg niludipine daily for 4--8 weeks
Route of Administration: Oral
In Vitro Use Guide
Curator's Comment: Effects of niludipine on isolated rabbit sinus node and right atrial preparations were studied using intracellular microelectrode techniques.
Niludipine in concentrations above 1 X 10(-8) M caused dose-dependent changes in the membrane action potentials of the preparations. Little change occurred in the MDP and MRD of atrial muscle fibers even at the highest concentration (1 X 10(-6) M).
Name Type Language
NILUDIPINE
INN   MART.  
INN  
Official Name English
BIS(2-PROPOXYETHYL) 1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE
Systematic Name English
NILUDIPINE [MART.]
Common Name English
BAY A 7168
Code English
niludipine [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C333
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
Code System Code Type Description
DRUG BANK
DB09240
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
NCI_THESAURUS
C76581
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
EVMPD
SUB09290MIG
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
ECHA (EC/EINECS)
245-120-6
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
INN
4319
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
PUBCHEM
89767
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
FDA UNII
9844OS3B0J
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
WIKIPEDIA
Niludipine
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
SMS_ID
100000083902
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106840
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
CAS
22609-73-0
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY
EPA CompTox
DTXSID20945267
Created by admin on Fri Dec 15 16:20:18 GMT 2023 , Edited by admin on Fri Dec 15 16:20:18 GMT 2023
PRIMARY