NILUDIPINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C25H34N2O8
Molecular Weight	490.5461
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCOCCOC(=O)C1=C(C)NC(C)=C(C1C2=CC=CC(=C2)[N+]([O-])=O)C(=O)OCCOCCC

InChI

InChIKey=VZWXXKDFACOXNT-UHFFFAOYSA-N

InChI=1S/C25H34N2O8/c1-5-10-32-12-14-34-24(28)21-17(3)26-18(4)22(25(29)35-15-13-33-11-6-2)23(21)19-8-7-9-20(16-19)27(30)31/h7-9,16,23,26H,5-6,10-15H2,1-4H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/7196733 | https://www.ncbi.nlm.nih.gov/pubmed/6540580 | https://www.ncbi.nlm.nih.gov/pubmed/7201809

Niludipine (Bay-a-7168) is a potent calcium antagonistic coronary vasodilator with less cardiodepressant effect than nifedipine. Niludipine is a safe antianginal Ca2+-antagonist with broad effectiveness for various types of angina pectoris. Niludipine is clinically useful as coronary vasodilator and hypotensive agent.

Originator

Approval Year

PubMed

Title	Date	PubMed
Acute and chronic hypotensive effects of nifedipine and niludipine in hypertensive patients with chronic renal failure.	1984	6432001
Effects of Ca antagonists, nifedipine, niludipine and verapamil, on endocrine function of the pancreas.	1983-06	6351351
Effects of new calcium channel blocker of niludipine on the coronary hemodynamics, diastolic properties, and metabolic responses to tachycardia stress in patients with coronary disease.	1982	7127462
Comparative coronary vasodilatory effects of nifedipine and niludipine.	1981	7196733
Antihypertensive effect of Niludipine (Bay a 7168) on conscious renal-hypertensive dogs.	1979	583244

Patents

Sample Use Guides

In Vivo Use Guide

Angina pectoris: Oral administration of from 60--120 mg niludipine daily for 4--8 weeks

Route of Administration: Oral

In Vitro Use Guide

Niludipine in concentrations above 1 X 10(-8) M caused dose-dependent changes in the membrane action potentials of the preparations. Little change occurred in the MDP and MRD of atrial muscle fibers even at the highest concentration (1 X 10(-6) M).

Name

Type

Language

BAY A 7168

Preferred Name

English

NILUDIPINE

Official Name

English

BIS(2-PROPOXYETHYL) 1,4-DIHYDRO-2,6-DIMETHYL-4-(M-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLATE

Systematic Name

English

NILUDIPINE [MART.]

Common Name

English

niludipine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C333