Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H24FN3O2 |
Molecular Weight | 381.4433 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
FC1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)N3C(=O)NC4=CC=CC=C34
InChI
InChIKey=FEBOTPHFXYHVPL-UHFFFAOYSA-N
InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,24,28)
Benperidol is a relatively old antipsychotic drug that has been marketed since 1966. It has been used in Germany for 30 years, but is also available in Belgium, Greece, Italy, the Netherlands and the UK. Benperidol is a drug which is a highly potent butyrophenone derivative. It is the most potent neuroleptic on the European market, with chlorpromazine equivalency as high as 75 to 100 (about 150 to 200% potency in terms of dose compared to haloperidol). Benperidol was discovered at Janssen Pharmaceutica in 1961. Benperidol is a potent dopamine receptor antagonist, with a high affinity for the D2-sites. The antipsychotic effects of this drug are primarily due to blockade of the D receptors. In terms of D receptor blockade, benperidol is one of the most potent antipsychotic agents, being approximately eight times more potent than haloperidol. Benperidol also acts as a dopamine antagonist in the chemoreceptor trigger zone, giving rise to antiemetic properties. It is also a weak antagonist at muscarinic, histamine H1, and alpha1-adrenoceptors. Adverse effects include extrapyramidal side effects and tardive dykinesia
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL217 Sources: http://www.ncbi.nlm.nih.gov/pubmed/15846648 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
---|---|---|
In vivo measurement of D2 receptor density and affinity for 18F-(3-N-methyl)benperidol in the rat striatum with a PET system for small laboratory animals. | 2003 Apr |
|
[Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. | 2006 Jun |
Patents
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Systematic Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Code | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-VATC |
QN05AD07
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
||
|
WHO-ATC |
N05AD07
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
||
|
NCI_THESAURUS |
C66883
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
100000086355
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
97O6X78C53
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
D001544
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
CHEMBL297302
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
312
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
DB12867
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
2062-84-2
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
BENPERIDOL
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
DTXSID7045364
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
C81086
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
16363
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
170982
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
m2320
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | Merck Index | ||
|
1373
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | RxNorm | ||
|
SUB05727MIG
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
218-172-2
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY | |||
|
1577
Created by
admin on Fri Dec 15 15:01:31 UTC 2023 , Edited by admin on Fri Dec 15 15:01:31 UTC 2023
|
PRIMARY |
ACTIVE MOIETY