Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H9Cl2N3O3 |
| Molecular Weight | 338.146 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=C(Cl)C=C(C=C1)C2=CC=C(O2)\C=N\N3CC(=O)NC3=O
InChI
InChIKey=HIQONTNPQNNMST-UBKPWBPPSA-N
InChI=1S/C14H9Cl2N3O3/c15-10-3-1-8(5-11(10)16)12-4-2-9(22-12)6-17-19-7-13(20)18-14(19)21/h1-6H,7H2,(H,18,20,21)/b17-6+
Clodanolene is a skeletal muscle contraction antagonist, closely related to dantrolene sodium. The drug has no measurable direct effect on the peripheral or central nervous systems. In a mouse of muscle spasticity (Straub-tail mouse), clodanolene induced skeletal muscle relaxation more effectively than neuromuscular blocking agents, local anesthetics, or centrally-acting muscle relaxants. Indirect evidence indicates clodanolene acts on caffeine-sensitive calcium stores in the muscle cells.
Approval Year
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NCI_THESAURUS |
C29696
Created by
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CHEMBL2106600
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3981
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100000084307
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C020999
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14796-28-2
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SUB06689MIG
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96L9G9BL3X
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DTXSID70864535
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C80981
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186557
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
