CZC-24832

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H17FN6O2S
Molecular Weight	364.398
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CN3N=C(N)N=C3C(F)=C2

InChI

InChIKey=RXRZPHQBTHQXSV-UHFFFAOYSA-N

InChI=1S/C15H17FN6O2S/c1-15(2,3)21-25(23,24)11-4-9(6-18-7-11)10-5-12(16)13-19-14(17)20-22(13)8-10/h4-8,21H,1-3H3,(H2,17,20)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22544264

CZC24832 is a highly selective and potent phosphoinositide 3-kinase γ (PI3Kγ) inhibitor. It dempnstrated efficacy in in vitro and in vivo models of inflammation.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
PI3-kinase p110-gamma subunit 32 Target ID: CHEMBL3267 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22544264	Inhibitor 8297		19.0 nM [Kd]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Arthritis 89 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22544264	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation.	2012 Apr 29	22544264
SAR studies around a series of triazolopyridines as potent and selective PI3Kγ inhibitors.	2012 Aug 15	22819766

Patents

Sample Use Guides

In Vivo Use Guide

10 mg/kg CZC24832 reduced the progression and severity of arthritis in a therapeutic mouse collagen-induced arthritis model.

Route of Administration: Oral

In Vitro Use Guide

CZC24832 was active in PI3Kγ-dependent cellular C5a-induced AKT Ser473 phosphorylation (IC50 = 1.2 μM) and fMLP-induced neutrophil migration assays (IC50 = 1.0 μM)

Name

Type

Language

CZC-24832

Code

English

5-(2-AMINO-8-FLUORO(1,2,4)TRIAZOLO(1,5-A)PYRIDIN-6-YL)-N-(1,1-DIMETHYLETHYL)-3-PYRIDINESULFONAMIDE

Systematic Name

English

CZC24832

Code

English

Code System Code Type Description

PUBCHEM

42623951

Created by admin on Sat Dec 16 18:08:18 GMT 2023 , Edited by admin on Sat Dec 16 18:08:18 GMT 2023

PRIMARY

CAS

1159824-67-5

Created by admin on Sat Dec 16 18:08:18 GMT 2023 , Edited by admin on Sat Dec 16 18:08:18 GMT 2023

PRIMARY

EPA CompTox

DTXSID50655226

Created by admin on Sat Dec 16 18:08:18 GMT 2023 , Edited by admin on Sat Dec 16 18:08:18 GMT 2023

PRIMARY

FDA UNII

96ER5DQD27

Created by admin on Sat Dec 16 18:08:18 GMT 2023 , Edited by admin on Sat Dec 16 18:08:18 GMT 2023

PRIMARY

ACTIVE MOIETY


					96ER5DQD27

CZC-24832

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/22544264

Originator

Approval Year

Targets

Conditions

Approved Use

PubMed

Patents

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22544264