Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C17H20O4 |
Molecular Weight | 288.3383 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 5 / 5 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12C[C@H](OC(C)=O)C(=C)[C@]1([H])[C@@]3([H])OC(=O)C(=C)[C@]3([H])CCC2=C
InChI
InChIKey=GKMFOEIZCLMZDE-QXKUPLGCSA-N
InChI=1S/C17H20O4/c1-8-5-6-12-9(2)17(19)21-16(12)15-10(3)14(7-13(8)15)20-11(4)18/h12-16H,1-3,5-7H2,4H3/t12-,13-,14-,15-,16-/m0/s1
Zaluzanin D is a sesquiterpene lactone that has been isolated from the aerial parts of Vernonia arborea as a major constituent (0.04%). Zaluzanin D isolated from laurel (Laurus nobilis L.) has being shown to induce cell death and morphological change indicative of apoptotic chromatin condensation in leukemia HL-60 cells. Zaluzanin D demonstrated antibacterial activity against Bacillus subtilis and Staphylococcus aureus.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL383 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12851709 |
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Target ID: CHEMBL352 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17680499 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12851709
Hypodiploid nuclei of HL 60 cells were increased to 12.4, 28.9 and 76.7% after a 3-day-treatment with 10, 15 and 20 uM zaluzanin D, respectively.
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SUBSTANCE RECORD