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Details

Stereochemistry ACHIRAL
Molecular Formula C12H11I3N2O5
Molecular Weight 643.9396
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOXITALAMIC ACID

SMILES

CC(=O)NC1=C(I)C(C(O)=O)=C(I)C(C(=O)NCCO)=C1I

InChI

InChIKey=OLAOYPRJVHUHCF-UHFFFAOYSA-N
InChI=1S/C12H11I3N2O5/c1-4(19)17-10-8(14)5(11(20)16-2-3-18)7(13)6(9(10)15)12(21)22/h18H,2-3H2,1H3,(H,16,20)(H,17,19)(H,21,22)

HIDE SMILES / InChI

Description

Ioxitalamic acid is a contrast media, which was used as a meglumine salt under the name Telebrix for intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography). The drug is no longer available on the market.

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8429
TELEBRIX

Approved Use

This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Diagnostic
Approved
8429
TELEBRIX

Approved Use

This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
Diagnostic
Approved
8429
TELEBRIX

Approved Use

This medicinal product is for diagnostic use only. Contrast agent to be used for: intravenous urography; computed tomography; digital angiography; angiocardiography (ventriculography, coronary angiography).
PubMed

PubMed

TitleDatePubMed
Evaluation of the nitric oxide production in rat renal artery smooth muscle cells culture exposed to radiocontrast agents.
2004 Feb
N-acetylcysteine attenuates iodine contrast agent-induced nephropathy in 5/6-nephrectomized rats.
2010
CT colonography with limited bowel preparation for the detection of colorectal neoplasia in an FOBT positive screening population.
2010 Dec
Patents

Patents

CN1803765 A
3

Sample Use Guides

In Vivo Use Guide
The recommended doses are 1.0 ml/kg (Intravenous urography); 1 and 1.8 ml/kg (computed tomography of brain and computed tomography of the whole body, respectively); 40 ml (ventriculography); 4-8 ml (coronary angiography). The solution for injection contains 350 mg iode/ml.
Route of Administration: Intravenous
In Vitro Use Guide
Ioxitalamic acid was added to human basophils and mast cells isolated from lung, skin, and heart tissue at concentration of 0.1 to 0.5 mol/L (Telebrix preparation). The drug induced histamine release from basophils and histamine and tryptase release from human heart mast cells.
Name Type Language
IOXITALAMIC ACID
INN   MART.   WHO-DD  
INN  
Official Name English
Ioxitalamic acid [WHO-DD]
Common Name English
AG 58107
Code English
AG-58107
Code English
IOXITHALAMIC ACID
Common Name English
ioxitalamic acid [INN]
Common Name English
IOXITALAMIC ACID [MART.]
Common Name English
5-ACETAMIDO-N-(2-HYDROXYETHYL)-2,4,6-TRIIODOISOPHTHALAMIC ACID
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C28500
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
WHO-VATC QV08AA05
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
WHO-ATC V08AA05
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
Code System Code Type Description
DRUG BANK
DB13444
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
EPA CompTox
DTXSID60182457
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
CAS
28179-44-4
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
ECHA (EC/EINECS)
248-887-5
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
SMS_ID
100000083117
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
PUBCHEM
34536
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
ChEMBL
CHEMBL2107239
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
DRUG CENTRAL
4582
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
FDA UNII
967RDI7Z6K
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
MESH
C002587
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
EVMPD
SUB08266MIG
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
NCI_THESAURUS
C65949
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
WIKIPEDIA
Ioxitalamic acid
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
INN
2742
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
CHEBI
83517
Created by admin on Fri Dec 15 16:25:10 GMT 2023 , Edited by admin on Fri Dec 15 16:25:10 GMT 2023
PRIMARY
SALT/SOLVATE (PARENT)
Structure of SODIUM IOXITHALAMATE
SALT/SOLVATE (PARENT)
Structure of MEGLUMINE IOXITHALAMATE
NIH
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