Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C5H11NO2Se |
Molecular Weight | 196.11 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 1 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C[Se]CC[C@H](N)C(O)=O
InChI
InChIKey=RJFAYQIBOAGBLC-BYPYZUCNSA-N
InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
DescriptionCurator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12656658 | https://examine.com/supplements/selenium
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/12656658 | https://examine.com/supplements/selenium
L-isomer of selenomethionine (Se-met) is a major natural food-form of selenium, synthetic L-Se-met or enriched food sources thereof such as selenium yeast are appropriate supplemental forms of Se for humans; for animals, DL-Se-met is acceptable. Ingested Se-met is either metabolized directly to reactive forms of selenium or stored in place of methionine in body proteins. Se-met metabolism is closely linked to protein turnover. Selenium, which is nutritionally essential for humans, is a constituent of more than two dozen selenoproteins that play critical roles in reproduction, thyroid hormone metabolism, DNA synthesis, and protection from oxidative damage and infection.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: WP408 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10867031 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Preventing | Selenium (selenomethionine) Approved UseSelenium (selenomethionine) is a natural antioxidant that delays the oxidation of polyunsaturated fatty acids and preserves the elasticity of tissue. Selenium is required for the production of certain prostaglandins, which promote healthy blood flow. In synergy with vitamin E, selenium promotes healthy growth and fertility, and improves the function of certain energy producing cells. Selenium also provides support for the immune system |
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Primary | Unknown Approved UseUnknown |
PubMed
Title | Date | PubMed |
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[Method of analysis of regional dynamics of the pancreas with 75Se-selenomethionine]. | 1977 Apr |
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Selenomethionine induction of DNA repair response in human fibroblasts. | 2002 May 23 |
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Selenium-containing compounds attenuate peroxynitrite-mediated NF-kappaB and AP-1 activation and interleukin-8 gene and protein expression in human leukocytes. | 2003 Nov 1 |
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Selenium metabolites in human urine after ingestion of selenite, L-selenomethionine, or DL-selenomethionine: a quantitative case study by HPLC/ICPMS. | 2005 Sep |
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The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding. | 2006 Aug 25 |
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Differential effects of naturally occurring and synthetic organoselenium compounds on biomarkers in androgen responsive and androgen independent human prostate carcinoma cells. | 2007 Apr 1 |
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Selenite reactivates silenced genes by modifying DNA methylation and histones in prostate cancer cells. | 2008 Nov |
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Regulation of cellular glutathione peroxidase by different forms and concentrations of selenium in primary cultured bovine hepatocytes. | 2010 Feb |
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Major differences among chemopreventive organoselenocompounds in the sustained elevation of cytoprotective genes. | 2012 Sep |
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Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). | 2013 Apr 15 |
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Effect of selenomethionine supplementation in food on the excretion and toxicity of arsenic exposure in female mice. | 2013 Dec |
Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12398336
10 or 50 uM selenomethionine protects against cadmium toxicity in cultured K-562 cells.
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Classification Tree | Code System | Code | ||
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DSLD |
2384 (Number of products:20)
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DSLD |
2033 (Number of products:7)
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NCI_THESAURUS |
C275
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EU-Orphan Drug |
EU/3/16/1782
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Code System | Code | Type | Description | ||
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SELENOMETHIONINE
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62621
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C2833
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CHEMBL113178
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D012645
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DTXSID8046824
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964MRK2PEL
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30021
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3544
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DB11142
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105024
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1611955
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964MRK2PEL
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3211-76-5
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100000128771
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SUB36255
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9644
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m9848
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3211-76-5
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760370
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ACTIVE MOIETY