AMPHOTALIDE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Possibly Marketed Outside US

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H20N2O3
Molecular Weight	324.3737
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of AMPHOTALIDE

Structure Search

SMILES

NC1=CC=C(OCCCCCN2C(=O)C3=CC=CC=C3C2=O)C=C1

InChI

InChIKey=GIIGAFADHXYOPM-UHFFFAOYSA-N

InChI=1S/C19H20N2O3/c20-14-8-10-15(11-9-14)24-13-5-1-4-12-21-18(22)16-6-2-3-7-17(16)19(21)23/h2-3,6-11H,1,4-5,12-13,20H2

HIDE SMILES / InChI

Description
Sources: (1967) Annual Reports in Medicinal Chemistry, v.2, page 139, retrieved from: https://books.google.ru/books?id=nnVxhG5GLXYC | https://www.drugfuture.com/chemdata/amphotalide.html | Burger, A. (1970) Medicinal chemistry, v.1, page 589, retrieved from: https://books.google.ru/books?id=zRBtAAAAMAAJ

Amphotalide is an anthelminthic drug. Antischistosomal agent. Amphotalide produced a definite therapeutic effect on S. haematobium infections but diminution of visual field was observed in several patients. The search was therefore continued for compounds devoid of retinal toxicity and more active than amphotalide in experimental animals.

Approval Year

Sample Use Guides

In Vivo Use Guide

In divided doses every 12 hours over a period of 5 or 6 days. Total amount - 250 mg per kg body weight

Route of Administration: Oral

Name

Type

Language

AMPHOTALIDE

Official Name

English

AMPHOTALIDE [MI]

Preferred Name

English

AMPHOTALIDE [MART.]

Common Name

English

N-(5-(P-AMINOPHENOXY)PENTYL)PHTHALIMIDE

Common Name

English

amphotalide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C250

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

Code System Code Type Description

DRUG CENTRAL

3674

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

EPA CompTox

DTXSID50862731

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

INN

1079

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

ECHA (EC/EINECS)

216-809-9

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

MERCK INDEX

m49

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

Merck Index

MESH

C005616

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

FDA UNII

95818EH730

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

CAS

1673-06-9

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

SMS_ID

100000086914

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

NCI_THESAURUS

C73155

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

PUBCHEM

71806

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

ChEMBL

CHEMBL94192

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

EVMPD

SUB05485MIG

Created by admin on Wed Apr 02 09:38:15 GMT 2025 , Edited by admin on Wed Apr 02 09:38:15 GMT 2025

PRIMARY

ACTIVE MOIETY


					95818EH730