Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H21NO3 |
| Molecular Weight | 299.3642 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1CC[C@@]23[C@H]4CCC(=O)[C@]2(C)OC5=C(O)C=CC(C[C@@H]14)=C35
InChI
InChIKey=NPZXCTIHHUUEEJ-CMKMFDCUSA-N
InChI=1S/C18H21NO3/c1-17-14(21)6-4-11-12-9-10-3-5-13(20)16(22-17)15(10)18(11,17)7-8-19(12)2/h3,5,11-12,20H,4,6-9H2,1-2H3/t11-,12+,17-,18-/m0/s1
Metopon was developed as an analgesic opium derivative. This drug has a high affinity to the mu-opioid receptor and produces antinociception through this receptor. Metopon was available in Canada only in tablet form for oral administration; however, because of the drug addiction, the Drug Addiction Committee recommended its limited use.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A comparison of the actions of meperidine, Nu-1196, methadone, morphine, Nu-2206, and metopon upon the intestine and uterus. | 1950-07 |
|
| Pharmacology of metopon and other new analgesic opium derivatives. | 1948-11-01 |
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| METOPON hydrochloride, alcohol-dextrose, dextrose vitamin solutions. | 1948-07 |
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| Metopon hydrochloride (methyldihydromorphinone hydrochloride). | 1948-01 |
|
| Metopon. | 1947-09 |
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| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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NCI_THESAURUS |
C67413
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DEA NO. |
9260
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| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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100000080922
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METOPON
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C83963
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m7497
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1785
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CHEMBL2110992
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5359353
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4189
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DTXSID20162275
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143-52-2
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C046877
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94XZ1CC69D
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SUB08909MIG
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PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)
