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Details

Stereochemistry ACHIRAL
Molecular Formula MoO4.2Na
Molecular Weight 205.92
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SODIUM MOLYBDATE

SMILES

[Na+].[Na+].[O-][Mo]([O-])(=O)=O

InChI

InChIKey=TVXXNOYZHKPKGW-UHFFFAOYSA-N
InChI=1S/Mo.2Na.4O/q;2*+1;;;2*-1

HIDE SMILES / InChI

Description

Molybdic acid refers to hydrated forms of molybdenum trioxide. There is no information related to the biological and pharmacological application of molybdic acid. It is known, that this substance is used as heterogeneous catalysts.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
For metabolically stable adults receiving TPN, the suggested additive dosage level is 20 to 120 mcg molybdenum/day. For pediatric patients, the additive dosage level should be calculated by extrapolation. In an adult, molybdenum deficiency state resulting from prolonged TPN support, intravenous administration of molybdenum as ammonium molybdate at 163 mcg/day for 21 days has been reported to reverse deficiency symptoms without toxicity.
Route of Administration: Intravenous
In Vitro Use Guide
Human prostate cancer cell line PC-3 were used for activity evaluation. PC-3 cells were plated onto 3.5-cm Petri dishes, incubated at 37 C for 24 h and treated with or without the Molybdate (2.0 mM) in the medium containing 10% FBS. At different time points, cells were washed twice with cold PBS– EDTA. Both floating and adherent cells were collected by trypsinization and centrifugation at 1,200g for 8 min. The cells were then fixed in 80% ethanol (-20 _C). Before analysis, the supernatant was removed by centrifugation at 2,000g for 5 min. Cells were washed once in cold PBS– EDTA, collected by centrifugation at 1,200g for 5 min, and resuspended in PBS–EDTA containing 40 lg/ml propidium iodide and 100 lg/ml ribonuclease A. The cell cycle distribution was analyzed by flow cytometry (FACSCalibur, BD Biosciences, San Jose, CA, USA) using CellQuest Pro (BD Biosciences).