CLOROPERONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H23ClFNO2
Molecular Weight	387.875
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=C1)C(=O)CCCN2CCC(CC2)C(=O)C3=CC=C(Cl)C=C3

InChI

InChIKey=OCXLBOACUPDBRL-UHFFFAOYSA-N

InChI=1S/C22H23ClFNO2/c23-19-7-3-17(4-8-19)22(27)18-11-14-25(15-12-18)13-1-2-21(26)16-5-9-20(24)10-6-16/h3-10,18H,1-2,11-15H2

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/31643 | https://www.ncbi.nlm.nih.gov/pubmed/1407003

Cloroperone (AHR 6134) is a derivative of butyrophenone with anxiolytic properties. In animals, cloroperone causes slight CNS depression in mice, prevents the lethal effects of d-amphetamine under crowded conditions in mice, suppresses emesis in dogs. The drug was investigated in the clinic for the treatment of psychotic patients. It was shown to be effective anxiolytic at low dosages without sedation, listlessness, drowsiness or neurologic reactions. Cloroperone is a selective binder to 5-HT2 receptors (Ki 4.5 nM).

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Serotonin 2 (5-HT2) receptor 90 Target ID: CHEMBL2095200 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1407003	Interacts 323		4.5 nM [Ki]

PubMed

Title	Date	PubMed
AHR 6134--a new anxiolytic drug with unusual clinical properties.	1978	31643

Patents

Name

Type

Language

4-(4-(P-CHLOROBENZOYL)PIPERIDINO)-4'-FLUOROBUTYROPHENONE

Preferred Name

English

CLOROPERONE

Official Name

English

cloroperone [INN]

Common Name

English

1-BUTANONE, 4-(4-(4-CHLOROBENZOYL)-1-PIPERIDINYL)-1-(4-FLUOROPHENYL)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28197