EPTALOPROST

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H34O5
Molecular Weight	402.5238
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCC#CC[C@H](C)[C@H](O)C#C[C@H]1[C@H](O)C[C@@H]2C\C(C[C@H]12)=C/COCCCC(O)=O

InChI

InChIKey=MAUUNYHAXGTMMQ-AMXXQSRZSA-N

InChI=1S/C24H34O5/c1-3-4-5-7-17(2)22(25)10-9-20-21-15-18(14-19(21)16-23(20)26)11-13-29-12-6-8-24(27)28/h11,17,19-23,25-26H,3,6-8,12-16H2,1-2H3,(H,27,28)/b18-11+/t17-,19-,20+,21-,22+,23+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1705084 | https://adisinsight.springer.com/drugs/800003249 | https://www.ncbi.nlm.nih.gov/pubmed/7692471

Eptaloprost is a novel concept PGI2-mimetic, which is designed to be activated to the pharmacologically potent cicaprost via beta-oxidation. Eptaloprost has a significant antimetastatic activity in a spontaneously metastasizing tumor model. Eptaloprost was undergoing phase I clinical trials with Schering AG in Germany for the treatment of cardiovascular disorders.

Originator

Approval Year

PubMed

Title	Date	PubMed
Bioactivation of eptaloprost in animals and man.	1993-08	7692471
Effects of prostacyclin analogues in in vivo tumor models.	1991	1705084

Patents

Name

Type

Language

EPTAPROST

Preferred Name

English

EPTALOPROST

Official Name

English

4-(2-((2E,3AS,4S,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-((3S,4S)-3-HYDROXY-4-METHYL-1,6-NONADIYNY)-2(1H)-PENTALENYLIDENE)ETHOXY)BUTYRIC ACID

Common Name

English

eptaloprost [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78568