U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C24H34O5
Molecular Weight 402.5238
Optical Activity UNSPECIFIED
Defined Stereocenters 6 / 6
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of EPTALOPROST

SMILES

[H][C@]12C[C@@H](O)[C@H](C#C[C@@H](O)[C@@H](C)CC#CCC)[C@@]1([H])C\C(C2)=C\COCCCC(O)=O

InChI

InChIKey=MAUUNYHAXGTMMQ-AMXXQSRZSA-N
InChI=1S/C24H34O5/c1-3-4-5-7-17(2)22(25)10-9-20-21-15-18(14-19(21)16-23(20)26)11-13-29-12-6-8-24(27)28/h11,17,19-23,25-26H,3,6-8,12-16H2,1-2H3,(H,27,28)/b18-11+/t17-,19-,20+,21-,22+,23+/m0/s1

HIDE SMILES / InChI
Eptaloprost is a novel concept PGI2-mimetic, which is designed to be activated to the pharmacologically potent cicaprost via beta-oxidation. Eptaloprost has a significant antimetastatic activity in a spontaneously metastasizing tumor model. Eptaloprost was undergoing phase I clinical trials with Schering AG in Germany for the treatment of cardiovascular disorders.

Approval Year

PubMed

PubMed

TitleDatePubMed
Patents

Patents

Name Type Language
EPTALOPROST
INN  
INN  
Official Name English
4-(2-((2E,3AS,4S,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-((3S,4S)-3-HYDROXY-4-METHYL-1,6-NONADIYNY)-2(1H)-PENTALENYLIDENE)ETHOXY)BUTYRIC ACID
Common Name English
eptaloprost [INN]
Common Name English
EPTAPROST
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C78568
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
Code System Code Type Description
FDA UNII
93X6A56W84
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
PRIMARY
MESH
C067428
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105604
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
PRIMARY
EPA CompTox
DTXSID70869060
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
PRIMARY
CAS
90693-76-8
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
PRIMARY
SMS_ID
100000084557
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
PRIMARY
NCI_THESAURUS
C65523
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
PRIMARY
EVMPD
SUB06592MIG
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
PRIMARY
INN
5825
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
PRIMARY
PUBCHEM
6436047
Created by admin on Fri Dec 15 15:41:04 GMT 2023 , Edited by admin on Fri Dec 15 15:41:04 GMT 2023
PRIMARY