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Details

Stereochemistry ACHIRAL
Molecular Formula C13H11As2N2O4S.2Na.H
Molecular Weight 488.133
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of NEOARSPHENAMINE DISODIUM

SMILES

[H+].[Na+].[Na+].NC1=C([O-])C=CC(=C1)\[As]=[As]\C2=CC(NCOS[O-])=C([O-])C=C2

InChI

InChIKey=KYSHZSXHSFTFGJ-UHFFFAOYSA-L
InChI=1S/C13H14As2N2O4S.2Na/c16-10-5-8(1-3-12(10)18)14-15-9-2-4-13(19)11(6-9)17-7-21-22-20;;/h1-6,17-20H,7,16H2;;/q;2*+1/p-2

HIDE SMILES / InChI

Description

Neoarsphenamine and related compounds are sulfhydryl-binding agents which are tolerated by man. A large experience in the employment of this drug and its toxic manifestations exists as a result of its former use as an antisyphilitic agent. Tertiary syphilis was a common cause for mental health conditions. Also known as Neosalvarsan, it superseded Salvarsan due to its lower toxicity. Both arsenicals still carried significant risk of side-effects and were themselves replaced by penicillin in the 1940s. Neoarsphenamine was also used for the treatment of amebic dysentery.

Approval Year

1912
10
PubMed

PubMed

TitleDatePubMed
Renal damage resulting from idiosyncrasy to neoarsphenamine.
1947-01

Sample Use Guides

In Vivo Use Guide
Intravenous injections of 0.3 g in the treatment of urinary tract infections and gonorrheal prostatitis
Route of Administration: Intravenous
In Vitro Use Guide
A buffered saline suspension containing approximately 2.5 x 10(7) cells/ml of M. sodonensis was made from a culture growing in log phase. The suspension was divided in half. To one portion neoarsphenamine was added to a concentration of 10(−3) M.
Name Type Language
NEO-ARSOLUIN DISODIUM
Preferred Name English
NEOARSPHENAMINE DISODIUM
WHO-DD  
Common Name English
METHANOL, (5-((3-AMINO-4-HYDROXYPHENYL)ARSENO)-2-HYDROXYANILINO)-, 1-(HYDROGEN SULFOXYLATE) (ESTER), DISODIUM SALT
Systematic Name English
NOVARSENOL DISODIUM
Common Name English
Neoarsphenamine disodium [WHO-DD]
Common Name English
SULFOXYLIC ACID, MONO(((5-((3-AMINO-4-HYDROXYPHENYL)DIARSENYL)-2-HYDROXYPHENYL)AMINO)METHYL) ESTER, SODIUM SALT (1:2)
Systematic Name English
SULFOXYLIC ACID, MONO(((5-((3-AMINO-4-HYDROXYPHENYL)DIARSENYL)-2-HYDROXYPHENYL)AMINO)METHYL) ESTER, DISODIUM SALT
Systematic Name English
NEOSALVARSAN DISODIUM
Common Name English
Code System Code Type Description
PUBCHEM
90479688
Created by admin on Mon Mar 31 22:06:09 GMT 2025 , Edited by admin on Mon Mar 31 22:06:09 GMT 2025
PRIMARY
EVMPD
SUB03405MIG
Created by admin on Mon Mar 31 22:06:09 GMT 2025 , Edited by admin on Mon Mar 31 22:06:09 GMT 2025
PRIMARY
SMS_ID
100000085712
Created by admin on Mon Mar 31 22:06:09 GMT 2025 , Edited by admin on Mon Mar 31 22:06:09 GMT 2025
PRIMARY
FDA UNII
92LBK3YOIY
Created by admin on Mon Mar 31 22:06:09 GMT 2025 , Edited by admin on Mon Mar 31 22:06:09 GMT 2025
PRIMARY
NIH
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