U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
7TM Pharma was developing obinepitide, a subcutaneously administered dual neuropeptide Y (NPY) Y2 and Y4 receptors agonist, for the treatment of obesity. Obinepitide is a synthetic analogue of two natural human hormones, PYY and Pancreatic Polypeptide, which normally are released during a meal. These hormones are known to play a role in the regulation of food intake and appetite in man as satiety signal from the GI-tract to the CNS. In obinepitide, the properties of both of these hormones have been implanted into a single molecule. Obinepitide targets the Y2 and Y4 receptors, with selectivity over the Y1 receptor, which is involved in causing cardiovascular side effects. Obinepitide inhibited food intake up to nine hours after dosing.

Approval Year

PubMed

PubMed

TitleDatePubMed
Structure-function studies on neuropeptide Y and pancreatic polypeptide--evidence for two PP-fold receptors in vas deferens.
1990 Sep 4
Name Type Language
OBINEPITIDE
INN  
INN  
Official Name English
obinepitide [INN]
Common Name English
(34-L-GLUTAMINE)PANCREATIC HORMONE (HUMAN)
Common Name English
Code System Code Type Description
CAS
348119-84-6
Created by admin on Sat Dec 16 17:56:57 GMT 2023 , Edited by admin on Sat Dec 16 17:56:57 GMT 2023
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DRUG BANK
DB05045
Created by admin on Sat Dec 16 17:56:57 GMT 2023 , Edited by admin on Sat Dec 16 17:56:57 GMT 2023
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NCI_THESAURUS
C175168
Created by admin on Sat Dec 16 17:56:57 GMT 2023 , Edited by admin on Sat Dec 16 17:56:57 GMT 2023
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INN
8799
Created by admin on Sat Dec 16 17:56:57 GMT 2023 , Edited by admin on Sat Dec 16 17:56:57 GMT 2023
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PUBCHEM
42629124
Created by admin on Sat Dec 16 17:56:57 GMT 2023 , Edited by admin on Sat Dec 16 17:56:57 GMT 2023
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FDA UNII
926PP306RV
Created by admin on Sat Dec 16 17:56:57 GMT 2023 , Edited by admin on Sat Dec 16 17:56:57 GMT 2023
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ChEMBL
CHEMBL2108338
Created by admin on Sat Dec 16 17:56:57 GMT 2023 , Edited by admin on Sat Dec 16 17:56:57 GMT 2023
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