Stereochemistry | ABSOLUTE |
Molecular Formula | C18H23N9O4S3 |
Molecular Weight | 525.628 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12SCC(CSC3=NN=NN3CCN(C)C)=C(N1C(=O)[C@H]2NC(=O)CC4=CSC(N)=N4)C(O)=O
InChI
InChIKey=QYQDKDWGWDOFFU-IUODEOHRSA-N
InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1
Cefotiam is a third generation beta-lactam cephalosporin antibiotic. It has broad spectrum activity against Gram positive and Gram negative bacteria. It does not have activity against Pseudomonas aeruginosa. The bactericidal activity of cefotiam results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
CNS Activity
Originator
Approval Year
Doses
Sourcing
PubMed
Sample Use Guides
Oral
Prophylaxis of surgical infections; Susceptible infections
Adult: 200-400 mg bid.
Parenteral
Prophylaxis of surgical infections; Susceptible infections
Adult: As hydrochloride: Up to 6 g daily IV/IM in divided doses according to severity of infection. As hexetil hydrochloride: 200-400 mg bid.
Route of Administration:
Other