Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C15H16N2O |
| Molecular Weight | 240.3003 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(CC1=CC=CC=C1)NC(=O)C2=CC=CN=C2
InChI
InChIKey=KJRJJAZBUWXZFN-UHFFFAOYSA-N
InChI=1S/C15H16N2O/c1-12(10-13-6-3-2-4-7-13)17-15(18)14-8-5-9-16-11-14/h2-9,11-12H,10H2,1H3,(H,17,18)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| N6-cyclohexyladenosine and 3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid enhance the effect of antiepileptic drugs against induced seizures in mice. | 2001-04-17 |
|
| The teratogenicity of anticonvulsant drugs. | 2001-04-12 |
|
| [Lamotrigine in refractory partial and general epilepsies]. | 2001-04-11 |
|
| Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: improved behavioral and neuroanatomical recovery with riluzole. | 2001-04 |
|
| Performance characteristics of four free phenytoin immunoassays. | 2001-04 |
|
| Rocuronium-induced neuromuscular blockade is affected by chronic phenytoin therapy. | 2001-04 |
|
| Stereoselective determination of p-hydroxyphenyl-phenylhydantoin enantiomers in rat liver microsomal incubates by reversed-phase high-performance liquid chromatography using beta-cyclodextrin as chiral mobile phase additives. | 2001-04 |
|
| Decreases in phenytoin hydroxylation activities catalyzed by liver microsomal cytochrome P450 enzymes in phenytoin-treated rats. | 2001-04 |
|
| Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors. | 2001-04 |
|
| Interaction of plasma proteins with cytochromes P450 mediated metabolic reactions: inhibition by human serum albumin and alpha-globulins of the debrisoquine 4-hydroxylation (CYP2D) in liver microsomes of human, hamster and rat. | 2001-03-08 |
|
| Volume-selective proton MR spectroscopy for in-vitro quantification of anticonvulsants. | 2001-03 |
|
| Fosphenytoin in infants of extremely low birth weight. | 2001-03 |
|
| Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice. | 2001-03 |
|
| Phenytoin-induced cleft palate: evidence for embryonic cardiac bradyarrhythmia due to inhibition of delayed rectifier K+ channels resulting in hypoxia-reoxygenation damage. | 2001-03 |
|
| [Febrile convulsions, Treatment and prognosis]. | 2001-02-19 |
|
| [Maintenance dose requirement for phenytoin is lowered in genetically impaired drug metabolism independent of concommitant use of other antiepileptics]. | 2001-02-17 |
|
| Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity. | 2001-02 |
|
| Determination of the antiepileptics vigabatrin and gabapentin in dosage forms and biological fluids using Hantzsch reaction. | 2001-02 |
|
| Refractory idiopathic status epilepticus. | 2001-02 |
|
| Cardiac arrest after fast intravenous infusion of phenytoin mistaken for fosphenytoin. | 2001-02 |
|
| Antiepileptic drug withdrawal in patients with temporal lobe epilepsy undergoing presurgical video-EEG monitoring. | 2001-02 |
|
| Fosphenytoin: pharmacokinetics and tolerance of intramuscular loading doses. | 2001-02 |
|
| Glutamate receptor antagonists differentially affect the protective activity of conventional antiepileptics against amygdala-kindled seizures in rats. | 2001-02 |
|
| Phenytoin intoxication induced by fluvoxamine. | 2001-02 |
|
| The effects of concomitant phenytoin administration on the steady-state pharmacokinetics of quetiapine. | 2001-02 |
|
| Rufinamide: a double-blind, placebo-controlled proof of principle trial in patients with epilepsy. | 2001-02 |
|
| Possible function of astrocyte cytochrome P450 in control of xenobiotic phenytoin in the brain: in vitro studies on murine astrocyte primary cultures. | 2001-02 |
|
| Myotoxicity studies of injectable biodegradable in-situ forming drug delivery systems. | 2001-01-05 |
|
| Interferon-alpha2a and 13-cis-retinoic acid with radiation treatment for high-grade glioma. | 2001-01 |
|
| Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors. | 2001-01 |
|
| Electrophysiological and pharmacological properties of the human brain type IIA Na+ channel expressed in a stable mammalian cell line. | 2001-01 |
|
| Hair analysis for pharmaceutical drugs. I. Effective extraction and determination of phenobarbital, phenytoin and their major metabolites in rat and human hair. | 2001-01 |
|
| Ritonavir-induced carbamazepine toxicity. | 2001-01 |
|
| Treatment of nonfebrile status epilepticus in Rochester, Minn, from 1965 through 1984. | 2001-01 |
|
| Effects of antiepileptic drugs on rat platelet aggregation: ex vivo and in vitro study. | 2001-01 |
|
| Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. | 2001-01 |
|
| Successful treatment of antiepileptic drug hypersensitivity syndrome with intravenous immune globulin. | 2001-01 |
|
| Drugs for discoid lupus erythematosus. | 2001 |
|
| II. An altered proliferation response due to the anticonvulsant phenytoin (PHT) in epileptic patients. | 2001 |
|
| I. The modulatory effect in genotoxic responses due to age and duration of PHT-therapy in epileptic patients. | 2001 |
|
| Acute fulminant hepatic failure in a woman treated with phenytoin and trimethoprim-sulfamethoxazole. | 2000-12 |
|
| Phenytoin, midazolam, and naloxone protect against fentanyl-induced brain damage in rats. | 2000-12 |
|
| Purple glove syndrome caused by oral administration of phenytoin. | 2000-11 |
|
| Effects of combined administration of zonisamide and valproic acid or phenytoin to nitric oxide production, monoamines and zonisamide concentrations in the brain of seizure-susceptible EL mice. | 2000-09-15 |
|
| Phenytoin poisoning after using Chinese proprietary medicines. | 2000-07 |
|
| Anticonvulsant-induced suppression of IFN-gamma production by lymphocytes obtained from cervical lymph nodes in glioma-bearing mice. | 2000-04 |
|
| Spasticity due to phenytoin toxicity. | 1979-03-10 |
|
| Procainamide and phenytoin. Comparative study of their antiarrhythmic effects at apparent therapeutic plasma levels. | 1975-07 |
|
| Harmful effect of megadoses of vitamins: electroencephalogram abnormalities and seizures induced by intravenous folate in drug-treated epileptics. | 1975-01 |
|
| The influence of aldosterone and anticonvulsant drugs on electroencephalographic and clinical disturbances induced by the spirolactone derivative, potassium canrenoate. | 1975-01 |
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139-68-4
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DTXSID40930271
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120640
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m8600
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90O34W851E
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53639
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SUBSTANCE RECORD
