MIDESTEINE

Details

Stereochemistry	MIXED
Molecular Formula	C12H13NO3S3
Molecular Weight	315.432
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(SC(=O)C1=CC=CS1)C(=O)NC2CCSC2=O

InChI

InChIKey=MKTVMEMIKNBVHI-UHFFFAOYSA-N

InChI=1S/C12H13NO3S3/c1-7(19-12(16)9-3-2-5-17-9)10(14)13-8-4-6-18-11(8)15/h2-3,5,7-8H,4,6H2,1H3,(H,13,14)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8836663 | https://adisinsight.springer.com/drugs/800003709

Midesteine (previously known as MR 889), a thiolactic acid derivative was developed as an inhibitor of the chymotrypsin and elastolytic activity of leukocyte elastase. Midesteine participated in clinical trials for patients with chronic obstructive pulmonary disease. The drug is also studied to treat asthma, cystic fibrosis, and emphysema. However, all these studies were discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial.	1996 Jul	8836663

Patents

Sample Use Guides

In Vivo Use Guide

Thirty subjects were administered MR889 orally at a dose of 500 mg b.i.d. for 4 weeks, and 30 received placebo following the same schedule.

Route of Administration: Oral

Name

Type

Language

MIDESTEINE

Official Name

English

2-THIOPHENECARBOTHIOIC ACID, S-ESTER WITH (±)-2-MERCAPTO-N-(TETRAHYDRO-2-OXO-3-THIENYL)PROPIONAMIDE

Common Name

English

N-(2-OXO-2,3,4,5-TETRAHYDRO-3-THIENYL)-2-(2-THIENYLCARBONYLTHIO)PROPIONAMIDE

Systematic Name

English

MR-889

Code

English

midesteine [INN]

Common Name

English

MR889

Code

English

Code System Code Type Description

ChEMBL

CHEMBL1808549