OXOLAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H19N3O
Molecular Weight	245.3202
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCN(CC)CCC1=NC(=NO1)C2=CC=CC=C2

InChI

InChIKey=IDCHQQSVJAAUQQ-UHFFFAOYSA-N

InChI=1S/C14H19N3O/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12/h5-9H,3-4,10-11H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ilacprospektusu.com/ilac/619/perebron-10-mg-120-ml-surup | https://www.ncbi.nlm.nih.gov/pubmed/13720535 | https://www.ncbi.nlm.nih.gov/pubmed/7140166

Oxolamine under brand names Symphocal, Perebron is used in some countries as a cough suppressant for the treatment of pharyngitis, tracheitis, bronchitis, bronchiectasis, pertussis. Oxolamine possesses anti-inflammatory activity, which causes a reduction in the irritation of the nervous receptors of the respiratory tract.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Cough 106 Sources: https://www.ilacprospektusu.com/ilac/619/perebron-10-mg-120-ml-surup	Palliative	Approved 8429	Perebron Approved Use Unknown
Tracheitis 3 Sources: https://www.ilacprospektusu.com/ilac/619/perebron-10-mg-120-ml-surup	Palliative	Approved 8429	Perebron Approved Use Unknown
Bronchitis 51 Sources: https://www.ilacprospektusu.com/ilac/619/perebron-10-mg-120-ml-surup	Palliative	Approved 8429	Perebron Approved Use Unknown
Pertussis 3 Sources: https://www.ilacprospektusu.com/ilac/619/perebron-10-mg-120-ml-surup	Palliative	Approved 8429	Perebron Approved Use Unknown

PubMed

Title	Date	PubMed
Effect of oxolamine on cough sensitivity in COPD patients.	2002 Jan	11863211
Effect of oxolamine on anticoagulant effect of warfarin.	2006 Jan 15	16390929
Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats.	2007 Apr	17295362

Patents

Sample Use Guides

In Vivo Use Guide

In general, 15-25 mg per kilogram per day should be given by dividing four equal doses. In children over 2 years: 1-2 ml of 5 ml Adults: 2 ml of 5 ml 4 times daily 4 hours a day, after an equal amount of water.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

OXOLAMINE

Official Name

English

5-(2-(DIETHYLAMINO)ETHYL)-3-PHENYL-1,2,4-OXADIAZOLE

Systematic Name

English

OKSALAMIN

Brand Name

English

OXOLAMINE [MI]

Common Name

English

SKF-9976 FREE BASE

Code

English

Oxolamine [WHO-DD]

Common Name

English

OXOLAMINE [MART.]

Common Name

English

oxolamine [INN]

Common Name

English

AF-438 FREE BASE

Code

English

SKF 9976 FREE BASE

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C257