Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H25NO2 |
| Molecular Weight | 215.3324 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NCCCCCCCCCCCC(O)=O
InChI
InChIKey=PBLZLIFKVPJDCO-UHFFFAOYSA-N
InChI=1S/C12H25NO2/c13-11-9-7-5-3-1-2-4-6-8-10-12(14)15/h1-11,13H2,(H,14,15)
12-aminododecanoic acid is used in industrial applications as a monomer for the manufacture of polyamide, polymers, thermoplastics, intermediate in the production of glue. 12-aminododecanoic acid has being used as a tether to crosslink interfacial peptides in the process of identification of potent HIV-1 protease dimerization inhibitors. 12-Aminododecanoic acid is also used in the laboratory as a reagent. Its main industrial use is as monomer or reactant. 12-Aminododecanoic acid is not known to cause remarkable adverse human health or environmental effects, but after repeated oral ingestion in rats, it showed adverse effects for kidney and hematological and blood chemical changes in the higher doses tested.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Simultaneous determination of berberine, palmatine, matrine, catechin and baicalin in Funing Shuan by micellar electrokinetic capillary chromatography-electrospray ionization mass spectrometry]. | 2010-07 |
|
| High yield synthesis of 12-aminolauric acid by "enzymatic transcrystallization" of omega-laurolactam using omega-laurolactam hydrolase from Acidovorax sp. T31. | 2009-05 |
|
| The screening, characterization, and use of omega-laurolactam hydrolase: a new enzymatic synthesis of 12-aminolauric acid. | 2008-08 |
|
| Molecular interactions alter clay and polymer structure in polymer clay nanocomposites. | 2008-04 |
|
| The impact of montmorillonite clay addition on the in vitro wear resistance of a glass-ionomer restorative. | 2007-04 |
|
| Self-assembled monolayers of alkanoic acids on the native oxide surface of SS316L by solution deposition. | 2007-02-27 |
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| Poly(ethylene terephthalate)/clay nanocomposites based on aminododecanoic acid-modified clay: effect of compatibilizer reactivity on clay dispersion. | 2006-12 |
|
| The influence of montmorillonite clay reinforcement on the performance of a glass ionomer restorative. | 2006-11 |
|
| Adsorption of fluorescently labeled protein residues on poly(ethylene-co-acrylic acid) films modified with affinity functionalities. | 2006-07-01 |
|
| A unidirectional crosslinking strategy for HIV-1 protease dimerization inhibitors. | 2004-08-16 |
Sample Use Guides
In Vivo Use Guide
Sources: https://euon.echa.europa.eu/lt/web/guest/registration-dossier/-/registered-dossier/12579/7/9/3
Curator's Comment: The test 12-aminododecanoic acid was administered by gavage to three groups each of ten male and ten female rats for up to fifty-four consecutive days, at dose levels of 50, 250 and 1000 mg/kg/day. A control group of ten males and ten females was dosed with vehicle alone (Arachis oil BP). Two recovery groups, each of five males and five females, were treated with the high dose (1000 mg/kg/day) or the vehicle alone for forty-two consecutive days and then maintained without treatment for a further fourteen days. Elevations in water consumption were detected throughout the treatment period for animals of either sex treated with 1000 or 250 mg/kg/day. In addition elevations in plasma urea were detected for females treated with 1000 or 250 mg/kg/day during blood analysis carried out at Day 14; and for 1000 mg/kg/day females at termination. These findings suggest impaired function of the kidneys.
Rats: 0, 50, 250 and 1000 mg/kg/day, oral, gavage
Route of Administration:
Oral
Inocula of 100 uL Pseudomonas sp. were used to seed 20 mL cultures of N-free M9 medium that had been supplemented with 200 mg of 12-aminododecanoic acid, which were then grown at 28°C for up to 1 month. Where growth was observed, cultures were streaked to single colonies on M9 agar (15%, w/v) supplemented with 10 mg mL−1 12-aminododecanoic acid.
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DTXSID90883480
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693-57-2
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211-754-7
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69661
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SUBSTANCE RECORD
