Details
| Stereochemistry | MIXED |
| Molecular Formula | C24H40O3 |
| Molecular Weight | 376.5726 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCC(C)(C)C1=CC(O)=C(C=C1)[C@@H]2C[C@H](O)CC[C@H]2CCCO
InChI
InChIKey=YNZFFALZMRAPHQ-SYYKKAFVSA-N
InChI=1S/C24H40O3/c1-4-5-6-7-14-24(2,3)19-11-13-21(23(27)16-19)22-17-20(26)12-10-18(22)9-8-15-25/h11,13,16,18,20,22,25-27H,4-10,12,14-15,17H2,1-3H3/t18-,20-,22-/m1/s1
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Cytotoxicity of synthetic cannabinoids on primary neuronal cells of the forebrain: the involvement of cannabinoid CB1 receptors and apoptotic cell death. | 2014-01-01 |
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| Cannabinoid-induced upregulation of serotonin 2A receptors in the hypothalamic paraventricular nucleus and anxiety-like behaviors in rats. | 2013-08-26 |
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| Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. | 2013-06-01 |
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| Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5-HT(2A)) receptor activity via ERK1/2 signaling. | 2013-03 |
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| Cannabinoid agonists increase the interaction between β-Arrestin 2 and ERK1/2 and upregulate β-Arrestin 2 and 5-HT(2A) receptors. | 2013-02 |
|
| Cannabinoid-induced enhanced interaction and protein levels of serotonin 5-HT(2A) and dopamine D₂ receptors in rat prefrontal cortex. | 2012-10 |
|
| Cytotoxicity of synthetic cannabinoids found in "Spice" products: the role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line. | 2011-11-10 |
|
| Cloning and pharmacological characterization of the dog cannabinoid CB₂receptor. | 2011-11-01 |
|
| Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands. | 2011-10-01 |
|
| The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. | 2011-06 |
|
| A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells. | 2011-05 |
|
| Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice. | 2010-09-29 |
|
| Effects of cannabinoid CB1 receptor agonism and antagonism on SKF81297-induced dyskinesia and haloperidol-induced dystonia in Cebus apella monkeys. | 2010-07-07 |
|
| Cannabinoid inhibition of macrophage migration to the trans-activating (Tat) protein of HIV-1 is linked to the CB(2) cannabinoid receptor. | 2010-04 |
|
| Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization. | 2009-10 |
|
| (Endo)cannabinoids mediate different Ca2+ entry mechanisms in human bronchial epithelial cells. | 2009-07 |
|
| Distribution and function of cannabinoid receptors 1 and 2 in the rat, monkey and human bladder. | 2009-04 |
|
| Concomitant activation of adenylyl cyclase suppresses the opposite influences of CB(1) cannabinoid receptor agonists on tyrosine hydroxylase expression. | 2009-01-15 |
|
| Reciprocal influences of CB1 cannabinoid receptor agonists on ERK and JNK signalling in N1E-115 cells. | 2008-11-26 |
|
| Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB1 receptor. | 2008-09 |
|
| Cannabinoids and hamster circadian activity rhythms. | 2008-07-30 |
|
| TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. | 2008-06-11 |
|
| Activation of endocannabinoid transmission induces antidepressant-like effects in rats. | 2008-06 |
|
| The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats. | 2007-12 |
|
| The orphan receptor GPR55 is a novel cannabinoid receptor. | 2007-12 |
|
| Chronologically overlapping occurrences of nicotine-induced anxiety- and depression-related behavioral symptoms: effects of anxiolytic and cannabinoid drugs. | 2007-09-18 |
|
| Agonist selective modulation of tyrosine hydroxylase expression by cannabinoid ligands in a murine neuroblastoma cell line. | 2007-09 |
|
| Virodhamine and CP55,940 modulate cAMP production and IL-8 release in human bronchial epithelial cells. | 2007-08 |
|
| Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin. | 2007-06-22 |
|
| Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors. | 2007-02 |
|
| Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol. | 2006-12 |
|
| Evaluation of the role of nicotinic acetylcholine receptor subtypes and cannabinoid system in the discriminative stimulus effects of nicotine in rats. | 2006-07-01 |
|
| Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: further evidence for an anxiolytic role for endogenous cannabinoid signaling. | 2006-07 |
|
| Systemic effect of cannabinoids on the spontaneous firing rate of locus coeruleus neurons in rats. | 2006-03-18 |
|
| F200A substitution in the third transmembrane helix of human cannabinoid CB1 receptor converts AM2233 from receptor agonist to inverse agonist. | 2006-02-15 |
|
| Effects of exogenous and endogenous cannabinoids on GABAergic neurotransmission between the caudate-putamen and the globus pallidus in the mouse. | 2006-02 |
|
| In silico patent searching reveals a new cannabinoid receptor. | 2006-01 |
|
| Cannabinoid action depends on phosphorylation of dopamine- and cAMP-regulated phosphoprotein of 32 kDa at the protein kinase A site in striatal projection neurons. | 2005-09-14 |
|
| The role of CB1 receptors in sweet versus fat reinforcement: effect of CB1 receptor deletion, CB1 receptor antagonism (SR141716A) and CB1 receptor agonism (CP-55940). | 2005-09 |
|
| Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain. | 1998-03-30 |
|
| Cannabinoid-induced hypotension and bradycardia in rats mediated by CB1-like cannabinoid receptors. | 1997-06 |
|
| Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. | 1996-09 |
|
| Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. | 1996-06-07 |
|
| Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. | 1996-05-01 |
|
| Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A. | 1996-03-22 |
|
| Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. | 1995-12-01 |
|
| Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. | 1995-09 |
|
| Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells. | 1995-06-09 |
|
| Molecular characterization of a peripheral receptor for cannabinoids. | 1993-09-02 |
|
| Molecular cloning of a human cannabinoid receptor which is also expressed in testis. | 1991-10-01 |
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| Code System | Code | Type | Description | ||
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DTXSID401017713
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8YX8JK1BQG
Created by
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CP 55940
Created by
admin on Mon Mar 31 22:35:56 GMT 2025 , Edited by admin on Mon Mar 31 22:35:56 GMT 2025
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83003-12-7
Created by
admin on Mon Mar 31 22:35:56 GMT 2025 , Edited by admin on Mon Mar 31 22:35:56 GMT 2025
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SUBSTANCE RECORD
