Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C23H21Cl2N5O2 |
| Molecular Weight | 469.352 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[11CH3]OC1=CC=C(C=C1)C2=C(C#N)C(=NN2C3=CC=C(Cl)C=C3Cl)C(=O)NN4CCCCC4
InChI
InChIKey=MCNQUWLLXZZZAC-BJUDXGSMSA-N
InChI=1S/C23H21Cl2N5O2/c1-32-17-8-5-15(6-9-17)22-18(14-26)21(23(31)28-29-11-3-2-4-12-29)27-30(22)20-10-7-16(24)13-19(20)25/h5-10,13H,2-4,11-12H2,1H3,(H,28,31)/i1-1
11C-JHU75528 (also known as 11C-OMAR) is a radiotracer with suitable imaging properties for quantification of cannabinoid receptor, CB1R in the human brain. 11C-JHU75528 is participating in an ongoing phase I clinical trial to examine whether the use of cannabis alters CB1R availability in females and if the severity of cannabis withdrawal is correlated with CB1 receptor availability.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| A new high-yield synthetic route to PET CB1 radioligands [11C]OMAR and its analogs. | 2012-06-01 |
|
| Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinity. | 2009-02 |
|
| 11C-JHU75528: a radiotracer for PET imaging of CB1 cannabinoid receptors. | 2006-10 |
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8YHH21923L
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DB14902
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11963742
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942063-86-7
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ACTIVE MOIETY
