PARAMETHASONE ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H31FO6
Molecular Weight	434.4977
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(C)=O

InChI

InChIKey=HYRKAAMZBDSJFJ-LFDBJOOHSA-N

InChI=1S/C24H31FO6/c1-12-7-16-15-9-18(25)17-8-14(27)5-6-22(17,3)21(15)19(28)10-23(16,4)24(12,30)20(29)11-31-13(2)26/h5-6,8,12,15-16,18-19,21,28,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21-,22+,23+,24+/m1/s1

HIDE SMILES / InChI

Description
Sources: http://www.medicatione.com/?c=drug&s=paramethasone%20acetate

Paramethasone acetate (a derivative of paramethasone) is a glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 173 Target ID: CHEMBL2034 Sources: Goulding, N, editor (2012). Glucocorticoids, p. 42. Retrieved from: \| https://books.google.ru/books?id=zm4FCAAAQBAJ&pg=PA40&lpg=PA40&dq=paramethasone+acetate+in+vitro&source=bl&ots=TCqwfqH9ds&sig=GAnVhziDVe1HYpj68MK9SpODNd4&hl=ru&sa=X&redir_esc=y#v=onepage&q=paramethasone%20acetate%20in%20vitro&f=false	Interacts 323

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatoid arthritis 320 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14451432	Primary		Approved 8583	HALDRONE Approved Use Paramethasone acetate (a derivative of paramethasone) is a glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone.

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L9FF9
BOC Sciences	1597-82-6
Chemieliva Pharmaceutical Co., Ltd	PBCM1203285
Chemspace	CSSB00102643706	https://chem-space.com/CSSB00102643706
Compound Cloud	443928
eMolecules	110068191
eNovation Chemicals	D674561	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674561
LGC Standards	DRE-C15848600	https://www.lgcstandards.com/US/en/p/DRE-C15848600
LGC Standards	LGCFOR1667.00	https://www.lgcstandards.com/US/en/p/LGCFOR1667.00
LGC Standards	MM1667.00	https://www.lgcstandards.com/US/en/p/MM1667.00
MuseChem	R018488	https://www.musechem.com/product/R018488.html
NovoSeek	443928
Toronto Research Chemicals	P191845
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd.	PH-0918N
ZINC	ZINC000004214095	http://zinc15.docking.org/substances/ZINC000004214095

PubMed

Title	Date	PubMed
[Trial of a new corticosteroid in suspension for local injections in rheumatology: paramethasone acetate].	1966-11	4862587
[TREATMENT OF 25 CASES OF ASCITIC CIRRHOSIS WITH PARAMETHASONE ACETATE. CLINICAL AND BIOLOGICAL STUDY].	1964-02	14146591
[Clinical investigation of paramethasone acetate in patients with rheumatoid arthritis].	1961-07-31	14451432

Patents

Sample Use Guides

In Vivo Use Guide

Paramethasone acetate is administered orally.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

PARAMETHASONE 21-ACETATE

Preferred Name

English

PARAMETHASONE ACETATE

Official Name

English

PARAMETHASONE ACETATE [MART.]

Common Name

English

Paramethasone acetate [WHO-DD]

Common Name

English

PARAMETHASONE ACETATE [USP IMPURITY]

Common Name

English

HALDRONE

Brand Name

English

PARAMETHASONE ACETATE [JAN]

Common Name

English

PARAMETHASONE 21-ACETATE [MI]

Common Name

English

PARAMETHASONE ACETATE [USAN]

Common Name

English

PARAMETHASONE ACETATE [ORANGE BOOK]

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 21-(ACETYLOXY)-6-FLUORO-11,17-DIHYDROXY-16-METHYL-, (6.ALPHA.,11.BETA.,16.ALPHA.)-

Systematic Name

English

6?-Fluoro-11?,17,21-trihydroxy-16?-methylpregna-1,4-diene-3,20-dione 21-acetate

Systematic Name

English

PARAMETHASONE ACETATE [VANDF]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521