PARAMETHASONE ACETATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H31FO6
Molecular Weight	434.4977
Optical Activity	UNSPECIFIED
Defined Stereocenters	9 / 9
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12C[C@@H](C)[C@](O)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]3([H])[C@@]2([H])C[C@H](F)C4=CC(=O)C=C[C@]34C

InChI

InChIKey=HYRKAAMZBDSJFJ-LFDBJOOHSA-N

InChI=1S/C24H31FO6/c1-12-7-16-15-9-18(25)17-8-14(27)5-6-22(17,3)21(15)19(28)10-23(16,4)24(12,30)20(29)11-31-13(2)26/h5-6,8,12,15-16,18-19,21,28,30H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21-,22+,23+,24+/m1/s1

HIDE SMILES / InChI

Description
Sources: http://www.medicatione.com/?c=drug&s=paramethasone%20acetate

Paramethasone acetate (a derivative of paramethasone) is a glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glucocorticoid receptor 172 Target ID: CHEMBL2034 Sources: Goulding, N, editor (2012). Glucocorticoids, p. 42. Retrieved from: \| https://books.google.ru/books?id=zm4FCAAAQBAJ&pg=PA40&lpg=PA40&dq=paramethasone+acetate+in+vitro&source=bl&ots=TCqwfqH9ds&sig=GAnVhziDVe1HYpj68MK9SpODNd4&hl=ru&sa=X&redir_esc=y#v=onepage&q=paramethasone%20acetate%20in%20vitro&f=false	Interacts 323

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatoid arthritis 316 Sources: https://www.ncbi.nlm.nih.gov/pubmed/14451432	Primary		Approved 8429	HALDRONE Approved Use Paramethasone acetate (a derivative of paramethasone) is a glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-retaining properties makes it less suitable than hydrocortisone with supplementary fludrocortisone.

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
substrate 1737 inhibitor 1587 inducer 781

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
		CYP3A5 76

Drug as perpetrator

Target	Modality	Activity	Metabolite
CYP3A4 1925	inducer 1573 Sources: https://go.drugbank.com/drugs/DB01384	yes	PARAMETHASONE 1
CYP3A4 1925	inhibitor 3277 Sources: https://go.drugbank.com/drugs/DB01384	yes	PARAMETHASONE 1
CYP3A5 130	inducer 1573 Sources: https://go.drugbank.com/drugs/DB01384	yes	PARAMETHASONE 1

Drug as victim

Target	Modality	Activity	Metabolite	Clinical evidence
CYP3A4 1737	substrate 3367 Sources: https://ncit-stage.nci.nih.gov/ncitbrowser/pages/concept_details.jsf?dictionary=NCI_Thesaurus&version=21.01d&code=C66309&ns=ncit&type=relationship&key=2023115890&b=1&n=0&vse=null	yes
CYP3A4 1737	substrate 3367 Sources: https://ncit-stage.nci.nih.gov/ncitbrowser/pages/concept_details.jsf?dictionary=NCI_Thesaurus&version=21.01d&code=C66309&ns=ncit&type=relationship&key=844391506&b=1&n=0&vse=null, https://go.drugbank.com/drugs/DB01384	yes	PARAMETHASONE 1

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L9FF9
BOC Sciences	1597-82-6
Chemieliva Pharmaceutical Co., Ltd	PBCM1203285
Chemspace	CSSB00102643706	https://chem-space.com/CSSB00102643706
Compound Cloud	443928
LGC Standards	DRE-C15848600	https://www.lgcstandards.com/US/en/p/DRE-C15848600
LGC Standards	LGCFOR1667.00	https://www.lgcstandards.com/US/en/p/LGCFOR1667.00
LGC Standards	MM1667.00	https://www.lgcstandards.com/US/en/p/MM1667.00
MuseChem	R018488	https://www.musechem.com/product/R018488.html
NovoSeek	443928
Toronto Research Chemicals	P191845
Yick-Vic Chemicals & Pharmaceuticals (HK) Ltd.	PH-0918N
ZINC	ZINC000004214095	http://zinc15.docking.org/substances/ZINC000004214095
eMolecules	110068191
eNovation Chemicals	D674561	https://www.enovationchem.com/ProductDetails.asp?ProductID=D674561

PubMed

Title	Date	PubMed
[Trial of a new corticosteroid in suspension for local injections in rheumatology: paramethasone acetate].	1966 Nov	4862587

Patents

Sample Use Guides

In Vivo Use Guide

Paramethasone acetate is administered orally.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Name

Type

Language

PARAMETHASONE ACETATE

Official Name

English

PARAMETHASONE ACETATE [MART.]

Common Name

English

PARAMETHASONE 21-ACETATE

Common Name

English

Paramethasone acetate [WHO-DD]

Common Name

English

PARAMETHASONE ACETATE [USP IMPURITY]

Common Name

English

HALDRONE

Brand Name

English

PARAMETHASONE ACETATE [JAN]

Common Name

English

PARAMETHASONE 21-ACETATE [MI]

Common Name

English

PARAMETHASONE ACETATE [USAN]

Common Name

English

PARAMETHASONE ACETATE [ORANGE BOOK]

Common Name

English

PREGNA-1,4-DIENE-3,20-DIONE, 21-(ACETYLOXY)-6-FLUORO-11,17-DIHYDROXY-16-METHYL-, (6.ALPHA.,11.BETA.,16.ALPHA.)-

Systematic Name

English

6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-acetate

Systematic Name

English

PARAMETHASONE ACETATE [VANDF]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C521