Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C27H32N2O3.2ClH |
| Molecular Weight | 505.476 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.COC1=C(OC)C=C(C=C1)C(O)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4
InChI
InChIKey=ZIGNSXDSBVYYFD-UHFFFAOYSA-N
InChI=1S/C27H32N2O3.2ClH/c1-31-25-14-13-23(19-26(25)32-2)24(30)20-28-15-17-29(18-16-28)27(21-9-5-3-6-10-21)22-11-7-4-8-12-22;;/h3-14,19,24,27,30H,15-18,20H2,1-2H3;2*1H
Tamolarizine (also known as NC-1100), an organic Ca2+ channel blocker, was studied in clinical trials phase II in patients with neurological disorders. However, these studies were discontinued. In addition, experiments on rodents have shown that tamolarizine treatment protected the hippocampus from ischemic brain damage and ameliorated place learning impairment. Tamolarizine was also able to reverse the multidrug-resistance phenotype in human leukemia K562 cells through direct interaction with P-glycoprotein.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Reversal of multidrug resistance in human leukemia K562 by tamolarizine, a novel calcium antagonist. | 2000-03 |
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| Ameliorative effects of tamolarizine on place learning impairment induced by transient forebrain ischemia in rats. | 2000-01-17 |
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| A new type of Ca2+ channel blocker, NC-1100, inhibits the low- and high-threshold Ca2+ currents in the rat CNS neurons. | 1992-12-11 |
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| Selectivity of cerebral vasodilators on basilar arteries. | 1986 |
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93035-33-7
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146395
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DTXSID50918762
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8W2G6APOWB
Created by
admin on Mon Mar 31 23:41:52 GMT 2025 , Edited by admin on Mon Mar 31 23:41:52 GMT 2025
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
