KRN-5500

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C28H43N7O7
Molecular Weight	589.6837
Optical Activity	UNSPECIFIED
Defined Stereocenters	6 / 6
E/Z Centers	2
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]1(O[C@H](NC2=NC=NC3=C2N=CN3)[C@H](O)[C@H](O)[C@H]1NC(=O)CNC(=O)\C=C\C=C\CCCCCCCCC)[C@@H](O)CO

InChI

InChIKey=LQIPDFIUPOYMPR-BKYURJJWSA-N

InChI=1S/C28H43N7O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-19(38)29-14-20(39)34-21-23(40)24(41)28(42-25(21)18(37)15-36)35-27-22-26(31-16-30-22)32-17-33-27/h10-13,16-18,21,23-25,28,36-37,40-41H,2-9,14-15H2,1H3,(H,29,38)(H,34,39)(H2,30,31,32,33,35)/b11-10+,13-12+/t18-,21+,23+,24+,25-,28-/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67092296 | https://www.ncbi.nlm.nih.gov/pubmed/10874212 | https://www.ncbi.nlm.nih.gov/pubmed/21983265

KRN-5500, a spicamycin derivative, is a nucleoside-like antibiotic with a broad spectrum of antitumor activity against human cancer cell lines. It also may have value in the treatment of neuropathic pain.

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Name

Type

Language

KRN-5500

Common Name

English

NSC-650426

Code

English

6-(4-DEOXY-4-((2E,4E)-TETRADECADIENOYLGLYCYL)AMINO-L-GLYCERO-B-L-MANNOHEPTOPYRANOSYL)AMINO-9H-PURINE

Common Name

English

SPK-241

Code

English

KRN5500

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

434414