Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C20H31NO2S.C6H8O7.H2O |
| Molecular Weight | 559.669 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.OC(=O)CC(O)(CC(O)=O)C(O)=O.O=C(OCCN1CCCCCC1)C(C2CCCCC2)C3=CSC=C3
InChI
InChIKey=YIIFJFQCZWTTCW-UHFFFAOYSA-N
InChI=1S/C20H31NO2S.C6H8O7.H2O/c22-20(23-14-13-21-11-6-1-2-7-12-21)19(18-10-15-24-16-18)17-8-4-3-5-9-17;7-3(8)1-6(13,5(11)12)2-4(9)10;/h10,15-17,19H,1-9,11-14H2;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2
Cetiedil is effective potassium channel blocker used as a peripheral vasodilator to treat patients with painful crises in sickle cell anemia and pain in the extremities caused by an arterial disease. Known pharmacological properties of the drug include vascular smooth muscle relaxation, inhibition of phosphodiesterase with the consequent increase in circulating cyclic AMP concentration, blockade of the effect of bradykinin and serotonin, analgesia, inhibition of platelet aggregation and the decrease of plasma and blood viscosity and plasma fibrinogen level. The antisickling effect of cetiedil is explained mainly in the light of the changes it induces in the activities of membrane-bound ATPases and the permeability properties of the erythrocyte membrane to cations and anions.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacology of the human red cell voltage-dependent cation channel; Part I. Activation by clotrimazole and analogues. | 2004-01-22 |
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| Inhibition of the antigen-induced activation of RBL-2H3 cells by cetiedil and some of its analogues. | 2004-01-12 |
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| Inhibition of the antigen-induced activation of RBL-2H3 cells by charybdotoxin and cetiedil. | 2004-01-12 |
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| An analysis of the mechanism by which cetiedil inhibits sickling. | 2002-01-18 |
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| Synthesis and structure-activity relationships of cetiedil analogues as blockers of the Ca(2+)-activated K+ permeability of erythrocytes. | 2001-09-27 |
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165411860
Created by
admin on Mon Mar 31 21:26:49 GMT 2025 , Edited by admin on Mon Mar 31 21:26:49 GMT 2025
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8VF7HHY5PF
Created by
admin on Mon Mar 31 21:26:49 GMT 2025 , Edited by admin on Mon Mar 31 21:26:49 GMT 2025
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PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
