Details
Stereochemistry | ACHIRAL |
Molecular Formula | C19H20N2O2 |
Molecular Weight | 308.3743 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC=C(\C=C2/CCCN=C2C3=CC=CN=C3)C(OC)=C1
InChI
InChIKey=RPYWXZCFYPVCNQ-RVDMUPIBSA-N
InChI=1S/C19H20N2O2/c1-22-17-8-7-14(18(12-17)23-2)11-15-5-4-10-21-19(15)16-6-3-9-20-13-16/h3,6-9,11-13H,4-5,10H2,1-2H3/b15-11+
GTS-21 (also known as DMBX-A), a selective alpha-7 nicotinic acetylcholine receptor agonist that has demonstrated memory and cognition enhancement activity in human clinical trials. GTS-21 has been studied in Phase II in patients with schizophrenia and in patients with Alzheimer disease. However, these studies were discontinued. GTS-21 was also involved in phase II to reduce negative affect, improve cognition and/or reduce smoking relapse in healthy adult men and women who are chronic cigarette smokers. However, this study was withdrawn. Besides, GTS-21 has participated in phase II to investigate safety and efficacy in adults with attention-deficit hyperactivity disorder.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P36544 Gene ID: 1139|||89832 Gene Symbol: CHRNA7 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15213292 |
11.0 µM [EC50] |
Sample Use Guides
In Vivo Use Guide
Sources: https://clinicaltrials.gov/ct2/show/NCT00419445
GTS21 25/75/150 mg tid
Route of Administration:
Oral
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NCT00952393
Created by
admin on Fri Dec 15 16:07:00 GMT 2023 , Edited by admin on Fri Dec 15 16:07:00 GMT 2023
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PRIMARY | Nicotinic Receptors and Schizophrenia | ||
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8S399XDN2K
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5310985
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GTS-21
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admin on Fri Dec 15 16:07:00 GMT 2023 , Edited by admin on Fri Dec 15 16:07:00 GMT 2023
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DB05708
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DTXSID701027513
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148372-04-7
Created by
admin on Fri Dec 15 16:07:00 GMT 2023 , Edited by admin on Fri Dec 15 16:07:00 GMT 2023
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ACTIVE MOIETY