Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C21H16N2O2S |
| Molecular Weight | 360.429 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC1=CC=C2C=CC=CC2=C1CC3=C(NC(=S)NC3=O)C4=CC=CC=C4
InChI
InChIKey=RVNSQVIUFZVNAU-UHFFFAOYSA-N
InChI=1S/C21H16N2O2S/c24-18-11-10-13-6-4-5-9-15(13)16(18)12-17-19(14-7-2-1-3-8-14)22-21(26)23-20(17)25/h1-11,24H,12H2,(H2,22,23,25,26)
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Oxidative nucleophilic substitution selectively produces cambinol derivatives with antiproliferative activity on bladder cancer cell lines. | 2019-01-01 |
|
| Ways to stop the spread of Alzheimer's disease. | 2018-07 |
|
| Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines. | 2018-06-01 |
|
| Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. | 2018-05-23 |
|
| Small Molecules as SIRT Modulators. | 2018 |
|
| A novel SIRT1 inhibitor, 4bb induces apoptosis in HCT116 human colon carcinoma cells partially by activating p53. | 2017-07-01 |
|
| Complex role of nicotinamide adenine dinucleotide in the regulation of programmed cell death pathways. | 2016-02-01 |
|
| The histone deacetylase inhibitor cambinol prevents acidic pHe-induced anterograde lysosome trafficking independently of sirtuin activity. | 2015-09 |
|
| The histone deacetylase sirtuin 2 is a new player in the regulation of platelet function. | 2015-07 |
|
| Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. | 2015 |
|
| Inhibition of SIRT1 signaling sensitizes the antitumor activity of silybin against human lung adenocarcinoma cells in vitro and in vivo. | 2014-07 |
|
| Development of pyrazolone and isoxazol-5-one cambinol analogues as sirtuin inhibitors. | 2014-04-24 |
|
| Frizzled 7 expression is positively regulated by SIRT1 and β-catenin in breast cancer cells. | 2014 |
|
| High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma. | 2013-10-02 |
|
| The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. | 2013-06 |
|
| Antitumor effect of SIRT1 inhibition in human HCC tumor models in vitro and in vivo. | 2013-04 |
|
| SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression. | 2013-03 |
|
| Cancer chemoprevention and nutriepigenetics: state of the art and future challenges. | 2013 |
|
| Sirtuin activators and inhibitors. | 2012-02-29 |
|
| Current advances in the synthesis and antitumoral activity of SIRT1-2 inhibitors by modulation of p53 and pro-apoptotic proteins. | 2012 |
|
| Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. | 2006-04-15 |
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Preferred Name | English | ||
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14513-15-6
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3246390
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8S2PHY4FNC
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DTXSID40390573
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112546
Created by
admin on Wed Apr 02 05:58:57 GMT 2025 , Edited by admin on Wed Apr 02 05:58:57 GMT 2025
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SUBSTANCE RECORD
