Details
Stereochemistry | EPIMERIC |
Molecular Formula | C16H21NO3 |
Molecular Weight | 275.3428 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 3 / 4 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(O)C3=CC=CC=C3
InChI
InChIKey=ZTVIKZXZYLEVOL-MCOXGKPRSA-N
InChI=1S/C16H21NO3/c1-17-12-7-8-13(17)10-14(9-12)20-16(19)15(18)11-5-3-2-4-6-11/h2-6,12-15,18H,7-10H2,1H3/t12-,13+,14+,15?
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
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Target ID: CHEMBL2094109 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Palliative | HYDROCODONE BITARTRATE AND HOMATROPINE METHYLBROMIDE Approved UseHydrocodone bitartrate and homatropine methylbromide syrup is indicated for the symptomatic relief of cough. Launch Date1983 |
PubMed
Title | Date | PubMed |
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Scavenging of photogenerated oxidative species by antimuscarinic drugs: atropine and derivatives. | 2002 |
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[Effect of pilocarpine and cycloplegic substances on ophthalmic tone in healthy eyes and ones with glaucoma]. | 2002 Jan-Feb |
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Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery. | 2002 Mar |
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Characterizing the subjective, psychomotor, and physiological effects of a hydrocodone combination product (Hycodan) in non-drug-abusing volunteers. | 2003 Jan |
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Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. | 2003 May |
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Homatropine and psychosis in Weill-Marchesani syndrome. | 2006 Jul |
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Pretreating rats with parenteral ophthalmic antimuscarinic agents decreases mortality from lethal organophosphate poisoning. | 2007 Apr |
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Enantioseparation of chiral tropa alkaloids by means of cyclodextrin-modified microemulsion electrokinetic chromatography. | 2007 Aug |
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Metoclopramide protection of diazinon-induced toxicosis in chickens. | 2007 Sep |
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Acute retinal necrosis complicating chickenpox in a healthy adult--a case report and review of literature. | 2007 Spring |
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Peripheral ulcerative keratitis with bilateral optic nerve involvement as an initial presentation of acute lymphocytic leukemia in an adult. | 2009 Feb |
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Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project. | 2010 |
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Tubulointerstitial nephritis with uveitis syndrome: A case report and review of literature. | 2010 Apr |
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Is homatropine 5% effective in reducing pain associated with corneal abrasion when compared with placebo? A randomized controlled trial. | 2010 Dec |
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Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | 2011 Jul 14 |
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Efficacy assessment of various anticholinergic agents against topical sarin-induced miosis and visual impairment in rats. | 2012 Apr |
Sample Use Guides
Adults and Adolescents 12 Years of Age and Older: 1 tablet or 5 mL (1 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 6 tablets or 30 mL (6 teaspoonfuls) in 24 hours. Children 6 to 11 Years of Age: 1/2 tablet or 2.5 mL (1/2 teaspoonful) of the oral solution every 4 to 6 hours as needed; do not exceed 3 tablets or 15 mL (3 teaspoonfuls) in 24 hours.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20085574
Isolated caprine urinary bladder detrusor muscle strips were incubated with homatropine at 5 uM after being contracted with 100 mum acetylcholine. The drug inhibited the ACh-induced contraction of the caprine detrusor and that this inhibition was reversed by raising the concentration of ACh.
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Classification Tree | Code System | Code | ||
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NDF-RT |
N0000000104
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NDF-RT |
N0000000104
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WHO-VATC |
QS01FA05
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NDF-RT |
N0000175840
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NDF-RT |
N0000000104
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NCI_THESAURUS |
C29704
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WHO-ATC |
S01FA05
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DB11181
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Homatropine
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1379
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m6038
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100000086705
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201-716-8
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8QS6WCL55Z
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CHEMBL1618018
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8QS6WCL55Z
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87-00-3
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C100236
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HOMATROPINE
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27084
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SUB02529MIG
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DTXSID6044014
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C61783
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)
SALT/SOLVATE (PARENT)