U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry RACEMIC
Molecular Formula C17H26N2O4S.ClH
Molecular Weight 390.925
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SULTOPRIDE HYDROCHLORIDE

SMILES

Cl.CCN1CCCC1CNC(=O)C2=CC(=CC=C2OC)S(=O)(=O)CC

InChI

InChIKey=IGOWMQPOGQYFFM-UHFFFAOYSA-N
InChI=1S/C17H26N2O4S.ClH/c1-4-19-10-6-7-13(19)12-18-17(20)15-11-14(24(21,22)5-2)8-9-16(15)23-3;/h8-9,11,13H,4-7,10,12H2,1-3H3,(H,18,20);1H

HIDE SMILES / InChI

Description

Sultopride (trade names Barnetil, Barnotil, Topral) is an atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia. It was launched by Sanofi-Aventis in 1976. Sultopride acts as a selective D2 and D3 receptor antagonist. It has also been shown to have clinically relevant affinity for the GHB receptor as well, a property it shares in common with amisulpride and sulpiride.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
4.5 nM [IC50]
3.8 nM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Barnetil
Primary
Barnetil

PubMed

Sample Use Guides

In Vivo Use Guide
Oral Psychoses: Adult: Acute and chronic psychoses: 400-800 mg daily. May also be given via IM inj. Oral Chronic aggression: Adult: 400-600 mg daily. Intramuscular Psychoses: Adult: Up to 800 mg daily.
Route of Administration: Oral
In Vitro Use Guide
In the presence of sultopride (30 and 100 uM) EADs (early afterdepolarisations) developed at plateau level.