NORBUDRINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C12H17NO3
Molecular Weight	223.2683
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(CNC1CCC1)C2=CC=C(O)C(O)=C2

InChI

InChIKey=OVTZNVCECJYMDW-UHFFFAOYSA-N

InChI=1S/C12H17NO3/c14-10-5-4-8(6-11(10)15)12(16)7-13-9-2-1-3-9/h4-6,9,12-16H,1-3,7H2

HIDE SMILES / InChI

Description
Sources: https://apps.who.int/iris/bitstream/handle/10665/275695/WHO-EMP-RHT-TSN-2018.1-eng.pdf?sequence=1&isAllowed=y | https://patents.google.com/patent/US4011258

Norbudrine (KWD2109) is a sympathomimetic drug. It is an active bronchospasmolytic agent. KWD2109 shows an in vitro bronchospasmolytic acitivity which is about 14 times better than that of KWD2025. In the in vivo tests or guinea pig bronchospasmolytic activity KWD2109 has an effect which is about 3 times that of KWD2025 after intraperitoneal and oral administration

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

The compound Norbudrine (KWD2109) and KWD2025 have been compared in preventing bronchospasm induced by histamine aerosol in guinea pigs. The drug was injected intraperitoneally 15 minutes or administered orally 30 minutes before histamine treatment. To study the duration of the effect, 2 mg/kg was administered orally to intact guinea pigs at different time intervals before the histamine treatment.

Route of Administration: Other

Name

Type

Language

NORBUDRINE

Official Name

English

RD-9338 FREE BASE

Code

English

NORBUTRINE

Common Name

English

.ALPHA.-((CYCLOBUTYLAMINO)METHYL)-3,4-DIHYDROXYBENZYL ALCOHOL

Systematic Name

English

KWD-2109 FREE BASE

Code

English

1,2-BENZENEDIOL, 4-(2-(CYCLOBUTYLAMINO)-1-HYDROXYETHYL)-

Systematic Name

English

RD 9338 FREE BASE

Code

English

1,2-BENZENEDIOL, 4-(2-(CYCLOBUTYLAMINO)-1-HYDROXYETHYL)-, (±)-

Systematic Name

English

norbudrine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C48149