Details
Stereochemistry | ACHIRAL |
Molecular Formula | C27H58N2O3.2FH |
Molecular Weight | 498.7737 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
F.F.CCCCCCCCCCCCCCCCCCN(CCO)CCCN(CCO)CCO
InChI
InChIKey=ZVVSSOQAYNYNPP-UHFFFAOYSA-N
InChI=1S/C27H58N2O3.2FH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-28(22-25-30)20-18-21-29(23-26-31)24-27-32;;/h30-32H,2-27H2,1H3;2*1H
DescriptionSources: http://www.codifa.it/farmaci/e/elmex-gel-dentale-gel-olaflur-e-dectaflur-e-sodio-fluoruro-anticariehttps://www.ncbi.nlm.nih.gov/pubmed/24604256Curator's Comment: description was created based on several sources, including
https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf
Sources: http://www.codifa.it/farmaci/e/elmex-gel-dentale-gel-olaflur-e-dectaflur-e-sodio-fluoruro-anticariehttps://www.ncbi.nlm.nih.gov/pubmed/24604256
Curator's Comment: description was created based on several sources, including
https://www.drugs.com/international/olaflur.html | https://www.ncbi.nlm.nih.gov/pubmed/15528912 | https://clinicaltrials.gov/ct2/show/record/NCT00268138 | https://www.old.health.gov.il/units/pharmacy/trufot/alonim/4872.pdf
Oleylamine (or oleamine) is a versatile and flexible reagent in synthesis as well as the desired surface ligand for the synthesis of nanoparticles. This compound is rather toxic to mammalian organism.
CNS Activity
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Epidemiology of 377 patients with chemical burns in Guangdong province. | 2004 Sep |
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Successful extracorporeal life support after potentially fatal pulmonary oedema caused by inhalation of nitric and hydrofluoric acid fumes. | 2007 Oct |
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Cytotoxicity of organic surface coating agents used for nanoparticles synthesis and stability. | 2015 Jun |
|
Allergic contact cheilitis caused by olaflur in toothpaste. | 2017 Jan |
Patents
Sample Use Guides
Brushing your teeth thoroughly with the preparation once a week. Just use elmex dental gel using a regular toothbrush for a period of 2-3 minutes, rinse normally. The total time of application (brushing and residence time) should not exceed five minutes.
Route of Administration:
Dental
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3183150
The outer 50-100 mkm of the surface of freshly extracted human incisors was removed by grinding and polishing, thus removing not only the pellicle from the surface but also the outer mineral layer, which in general shows the greatest variation in chemical constituents. Amine fluoride 297 (AmF 297) were dissolved in distilled water. After adsorption of aminefluorides on the enamel for 2 min at a volume to area ratio of 25 cm3/cm2, the enamel surfaces were rinsed with distilled water and allowed to dry for several hours at room temperature in an enclosed chamber. Subsequently adsorbed layer thicknesses were determined by ellipsometry, and surface free energies were calculated from contact angle data.
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C175173
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OLAFLUR
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ACTIVE MOIETY
SUBSTANCE RECORD