Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C8H13N3O5S |
| Molecular Weight | 263.271 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CNC(=O)CNC(=O)CNC(=O)CS
InChI
InChIKey=RXACEEPNTRHYBQ-UHFFFAOYSA-N
InChI=1S/C8H13N3O5S/c12-5(2-10-7(14)4-17)9-1-6(13)11-3-8(15)16/h17H,1-4H2,(H,9,12)(H,10,14)(H,11,13)(H,15,16)
Mertiatide (mercaptoacetylglycylglycylglycine (MAG3) is a technetium-chelating agent based on a triamide monomercaptide tetradentate set of donor groups. Radioisotope complex technetium 99m mertiatide is used as the agent of choice for renal scintigraphy, diuresis renography, captopril augmented renography, and renal transplant.
Originator
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent. | 2006-12 |
|
| New N(3)S donor ligand small peptide analogues of the N-mercaptoacetyl-glycylglycylglycine ligand in the clinically used Tc-99m renal imaging agent: evidence for unusual amide oxygen coordination by two new ligands. | 2002-06-03 |
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| 99mTc-MAG3: review of pharmacokinetics, clinical application to renal diseases and quantification of renal function. | 2001-06 |
|
| [A case of renal cell carcinoma diagnosed by MAG3 scintigraphy because of moderate renal dysfunction]. | 2001-03 |
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| Synthesis and biological evaluation of technetium-99m MAG3 as a hippuran replacement. | 1986-01 |
Patents
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Preferred Name | English | ||
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C390
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66516-09-4
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C66099
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SUB08780MIG
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100000081733
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
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