CHLORMIDAZOLE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H13ClN2
Molecular Weight	256.73
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=NC2=CC=CC=C2N1CC3=CC=C(Cl)C=C3

InChI

InChIKey=WNAQOLSMVPFGTE-UHFFFAOYSA-N

InChI=1S/C15H13ClN2/c1-11-17-14-4-2-3-5-15(14)18(11)10-12-6-8-13(16)9-7-12/h2-9H,10H2,1H3

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Description
Sources: http://leki-opinie.pl/polfungicid-plyn | https://www.ncbi.nlm.nih.gov/pubmed/945306 | https://www.ncbi.nlm.nih.gov/pubmed/2395759

Chlormidazole was the first azole introduced the treatment of topical mycosis. It demonstrated inhibitory activity against many fungi and some gram-positive cocci. It is used for the treatment of fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses. Possible side effects are: local skin irritation, burning, itching.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dermatomycosis 20 Sources: https://www.ncbi.nlm.nih.gov/pubmed/725113 https://www.ncbi.nlm.nih.gov/pubmed/129703 https://www.ncbi.nlm.nih.gov/pubmed/945306	Curative		Approved 8429	Myco-polycid Approved Use Indicated for the treatment of fungal and fungal-bacterial (mixed) skin and nail infections (including interdigital and periungual mycoses).

PubMed

Title	Date	PubMed
[Clinical results in treatment of dermatomycoses with Myco-Polycid].	1973 Dec	4589249
[Efficacy of the Myco-Polycid preparation in the form of tincture and cream for the treatment of dermatomycoses].	1975 Dec	129703
[Treatment of dermatomycoses with Myco-Polycid].	1975 May	1160933
Topical pharmacology of imidazole antifungals.	1976	945306
[Antibacterial and antifungal compounds. V. Synthesis and antimicrobial activity of N-(2-arylethylaminophenyl)-1H-pyrryl-1-amine and 1-(1H-pyrrol-1-yl)-2-arylmethylbenzimidazole)].	1985 Jul	4043374
[Sensitivity of aerobic bacteria and Candida species to chlormidazole hydrochloride in vitro].	1990 Jan 22-29	2395759
Azole antimycotics--a highway to new drugs or a dead end?	2012	22257053

Patents

Sample Use Guides

In Vivo Use Guide

2-3 times per day; Treatment should be continued for at least 4 weeks after complete elimination of discomfort.

Route of Administration: Topical

In Vitro Use Guide

Over 100 bacterial stains, including Candida sp., gram-positive cocci and some gram-negative bacilli, were tested. The majority of microorganisms was isolated from man. Only one bacterial strain (5 ug/mL) and 76% of Candida strains were sensitive to chlormidazole HCl (10 ug/mL).

Name

Type

Language

CHLORMIDAZOLE

Official Name

English

Chlormidazole [WHO-DD]

Common Name

English

chlormidazole [INN]

Common Name

English

CHLORMIDAZOLE [MI]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QD01AC04