Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C19H26NO4 |
Molecular Weight | 332.414 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 6 / 7 |
E/Z Centers | 0 |
Charge | 1 |
SHOW SMILES / InChI
SMILES
[H][C@@]12O[C@]1([H])[C@H]3C[C@H](C[C@@H]2[N@@+]3(C)CC)OC(=O)[C@H](CO)C4=CC=CC=C4
InChI
InChIKey=NVOYVOBDTVTBDX-PMEUIYRNSA-N
InChI=1S/C19H26NO4/c1-3-20(2)15-9-13(10-16(20)18-17(15)24-18)23-19(22)14(11-21)12-7-5-4-6-8-12/h4-8,13-18,21H,3,9-11H2,1-2H3/q+1/t13-,14-,15-,16+,17-,18+,20?/m1/s1
DescriptionSources: http://www.ncbi.nlm.nih.gov/pubmed/1935594Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/17594728
Sources: http://www.ncbi.nlm.nih.gov/pubmed/1935594
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/17594728
Oxitropium bromide (trade names Oxivent, Tersigan) is a bronchodilator indicated for asthma and chronic obstructive pulmonary disease. Oxitropium’s bronchodilation effect is similar to that of ipratropium bromide, but oxitropium is longer-lasting. The usual dose is 200 ug, 2–3 times daily. It blocks the muscarinic cholinergic receptors which mediate smooth muscle contraction in the airways. The manufacturer claims that regular use of oxitropium (200μg twice or three times daily) reduces the incidence of symptoms, including the need for night-time bronchodilators, and improves lung function in some patients; it is not intended for immediate symptom relief. Although widely used for many years (alone or in combination with short-acting beta agonists) for both maintenance treatment of stable disease and exacerbation of airway obstruction, Boehringer Ingelheim announced the discontinuation of Oxivent formulations at May 2004.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL2094109 Sources: https://www.ncbi.nlm.nih.gov/pubmed/2770056 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
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Sources: http://www.ncbi.nlm.nih.gov/pubmed/1935594 |
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: http://infomed.for9.net/blog/oxivent-oxitropium/
2 puffs two to three times daily
Route of Administration:
Respiratory
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2770056
The effect of oxitropium bromide (Ba253) on the resting tonus and agonist-induced contraction of isolated guinea pig airway smooth muscle and on the anaphylactic release of histamine and immunoreactive leukotrienes (i-LTs) from lung fragments were investigated. Ba253 dose-dependently inhibited the acetylcholine (ACh)-induced contraction of the isolated trachea and lung parenchyma.
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NCI_THESAURUS |
C29704
Created by
admin on Fri Dec 15 16:47:19 GMT 2023 , Edited by admin on Fri Dec 15 16:47:19 GMT 2023
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C87641
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2022
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32649
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8G15T83E6I
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C017590
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DB12086
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SUB03574MIG
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DTXSID9048144
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6917866
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99571-64-9
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100000085507
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)