U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C19H17ClN2O4
Molecular Weight 372.802
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of OXAMETACIN

SMILES

COC1=CC2=C(C=C1)N(C(=O)C3=CC=C(Cl)C=C3)C(C)=C2CC(=O)NO

InChI

InChIKey=AJRNYCDWNITGHF-UHFFFAOYSA-N
InChI=1S/C19H17ClN2O4/c1-11-15(10-18(23)21-25)16-9-14(26-2)7-8-17(16)22(11)19(24)12-3-5-13(20)6-4-12/h3-9,25H,10H2,1-2H3,(H,21,23)

HIDE SMILES / InChI
Oxametacin (1-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolylacethydroxamic acid) is a non-steroidal anti-inflammatory compound that exerts analgesic, antipyretic and anti-inflammatory properties. This drug has been claimed to be effective in the treatment of acute attacks of gout. In the antiproliferative test, oxametacin exhibited leukemic cell lines selectivity against the solid tumor cell lines. Oxametacin also exhibited inhibitory activity toward histone deacetylases and thus could be used as a lead compound in the further development of histone deacetylase inhibitors for anticancer therapy.

Approval Year

Targets

Targets

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Primary
Name Type Language
OXAMETACIN
INN   MART.   WHO-DD  
INN  
Official Name English
Oxametacine
Common Name English
Oxametacin [WHO-DD]
Common Name English
oxametacin [INN]
Common Name English
OXAMETACIN [MART.]
Common Name English
OXAMETACINE [MI]
Common Name English
1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETOHYDROXAMIC ACID
Common Name English
Classification Tree Code System Code
WHO-ATC M01AB13
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
NCI_THESAURUS C257
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
WHO-VATC QM01AB13
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
Code System Code Type Description
FDA UNII
8G02RSW5CM
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
DRUG CENTRAL
2008
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
INN
4223
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
EPA CompTox
DTXSID70181517
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
WIKIPEDIA
Oxametacin
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
ChEMBL
CHEMBL295829
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
CHEBI
76255
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
SMS_ID
100000083581
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
MERCK INDEX
m8285
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY Merck Index
PUBCHEM
33675
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
EVMPD
SUB09492MIG
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
CAS
27035-30-9
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
NCI_THESAURUS
C76077
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
DRUG BANK
DB13308
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY
ECHA (EC/EINECS)
248-179-6
Created by admin on Fri Dec 15 16:30:30 GMT 2023 , Edited by admin on Fri Dec 15 16:30:30 GMT 2023
PRIMARY