Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H29N3S2 |
Molecular Weight | 399.616 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCSC1=CC=C2SC3=C(C=CC=C3)N(CCCN4CCN(C)CC4)C2=C1
InChI
InChIKey=XCTYLCDETUVOIP-UHFFFAOYSA-N
InChI=1S/C22H29N3S2/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24/h4-5,7-10,17H,3,6,11-16H2,1-2H3
Thiethylperazine is a antiemetic, which was used for the treatment of nausea and vomiting in patients undergoing radiotherapy, chemotherapy or as a postoperative care. Thiethylperazine exerts its therapeutic effect by blocking dopamine receptors in brain. The drug is capable of potentiating CNS depressants as well as atropine.
CNS Activity
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Secondary | TORECAN Approved UseTo relieve nausea and vomitin associated with postoperative recovery, radiation therapy, chemotherapy, acute situations. Launch Date-2.66889593E11 |
|||
Secondary | TORECAN Approved UseTo relieve nausea and vomitin associated with postoperative recovery, radiation therapy, chemotherapy, acute situations. Launch Date-2.66889593E11 |
Doses
Dose | Population | Adverse events |
---|---|---|
100 mg 1 times / day single, oral Overdose Dose: 100 mg, 1 times / day Route: oral Route: single Dose: 100 mg, 1 times / day Sources: |
unhealthy, 12 n = 1 Health Status: unhealthy Condition: migraine Age Group: 12 Sex: F Population Size: 1 Sources: |
Other AEs: Dystonia, Hyperreflexia... |
150 mg 6 times / day multiple, oral (max) Highest studied dose Dose: 150 mg, 6 times / day Route: oral Route: multiple Dose: 150 mg, 6 times / day Sources: |
unhealthy, 22-53 n = 10 Health Status: unhealthy Condition: schizophrenia Age Group: 22-53 Sex: M+F Population Size: 10 Sources: |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Dystonia | 100 mg 1 times / day single, oral Overdose Dose: 100 mg, 1 times / day Route: oral Route: single Dose: 100 mg, 1 times / day Sources: |
unhealthy, 12 n = 1 Health Status: unhealthy Condition: migraine Age Group: 12 Sex: F Population Size: 1 Sources: |
|
Hyperreflexia | 100 mg 1 times / day single, oral Overdose Dose: 100 mg, 1 times / day Route: oral Route: single Dose: 100 mg, 1 times / day Sources: |
unhealthy, 12 n = 1 Health Status: unhealthy Condition: migraine Age Group: 12 Sex: F Population Size: 1 Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
[Extrapyramidal syndrome as a side-effect of treatment with thiethylperazine (torecan) and metoclopramide (Reglan) a review of ten cases (author's transl)]. | 1977 Mar |
|
Preliminary results. UFT/methotrexate/leucovorin for breast Ca patients in progression after HDCT/PBPC support. | 1997 Sep |
|
Cannabinoids for control of chemotherapy induced nausea and vomiting: quantitative systematic review. | 2001 Jul 7 |
|
Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. | 2003 May |
|
Thiethylperazine-induced parkinsonism: in vivo demonstration of dopamine D2 receptors blockade. | 2004 Oct |
Patents
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-VATC |
QR06AD03
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
||
|
WHO-ATC |
R06AD03
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
||
|
NCI_THESAURUS |
C267
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
2630
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
1034
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
DB00372
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
9544
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
m10737
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | Merck Index | ||
|
Thiethylperazine
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
C62081
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
1420-55-9
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
THIETHYLPERAZINE
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
8ETK1WAF6R
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
CHEMBL1378
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
7306
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
5440
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
10471
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | RxNorm | ||
|
215-819-0
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
DTXSID1023651
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
SUB10973MIG
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
3400
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
100000082399
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY | |||
|
D013847
Created by
admin on Sat Dec 16 16:20:56 UTC 2023 , Edited by admin on Sat Dec 16 16:20:56 UTC 2023
|
PRIMARY |
ACTIVE MOIETY
SALT/SOLVATE (PARENT)