Details
Stereochemistry | RACEMIC |
Molecular Formula | C11H15NO |
Molecular Weight | 177.2429 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC(C)C(=O)C1=CC=C(C)C=C1
InChI
InChIKey=YELGFTGWJGBAQU-UHFFFAOYSA-N
InChI=1S/C11H15NO/c1-8-4-6-10(7-5-8)11(13)9(2)12-3/h4-7,9,12H,1-3H3
Mephedrone (4-methylmethcathinone) is a β-ketoamphetamine belonging to the family of synthetic cathinones, an emerging class of designer drugs known for their hallucinogenic and psychostimulant properties as well as for their abuse potential. Mephedrone is a stimulant of dopamine (DA) release and blocks its reuptake through its interaction with the dopamine transporter. Furthermore, it has some affinity for various 5-hydroxytryptamine (5-HT) receptor subtypes. Neurotoxic effect of mephedrone on 5-HT and DA systems remains controversial. Although some studies in animal models reported no damage to DA nerve endings in the striatum and no significant changes in brain monoamine levels, some others suggested a rapid reduction in 5-HT and DA transporter function. Persistent serotonergic deficits were observed after binge like treatment in a warm environment and in both serotonergic and dopaminergic nerve endings at high ambient temperature. Oxidative stress cytotoxicity and an increase in frontal cortex lipid peroxidation were also reported. Despite the re-classification of mephedrone as a Class B restricted substance by the United Kingdom and restrictive legislation by the United States, international policy regarding mephedrone control is still developing and interest in synthetic amphetamine-like drugs could drive the development of future mephedrone analogues.
Approval Year
PubMed
Title | Date | PubMed |
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A collapse in integrity of scientific advice in the UK. | 2010 Apr 17 |
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A harmless high? | 2010 Aug 28 |
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An analysis of the 'legal high' mephedrone. | 2010 Jul 15 |
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[Mephedrone: A designer drug legally available on the Web]. | 2010 Jul-Aug |
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Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometry. | 2010 Jun |
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Dependence and psychosis with 4-methylmethcathinone (mephedrone) use. | 2010 Nov 3 |
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Mephedrone: still available and twice the price. | 2010 Nov 6 |
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The serotonin syndrome as a result of mephedrone toxicity. | 2010 Sep 20 |
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Clinical characteristics of mephedrone toxicity reported to the U.K. National Poisons Information Service. | 2011 Aug |
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Instability of the ecstasy market and a new kid on the block: mephedrone. | 2011 Nov |
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1248
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admin on Sat Dec 16 00:23:35 GMT 2023 , Edited by admin on Sat Dec 16 00:23:35 GMT 2023
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WIKIPEDIA |
Designer-drugs-4-Methylmethcathinone
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DB13108
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MEPHEDRONE
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ACTIVE MOIETY
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