DescriptionCurator's Comment: description was created based on several sources, including
https://www.nap.edu/read/13142/chapter/6 |
https://www.drugs.com/pro/formaldehyde-liquid.html
Curator's Comment: description was created based on several sources, including
https://www.nap.edu/read/13142/chapter/6 |
https://www.drugs.com/pro/formaldehyde-liquid.html
Formaldehyde is a naturally occurring organic compound, and an important industrial precursor to many other materials and organic compounds. Formaldehyde solution (formalin) is used as a disinfectant. Formaldehyde vapors are toxic, upon entry formaldehyde reacts readily with macromolecules, including DNA to form DNA-protein and DNA-DNA cross-links.
CNS Activity
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL2311221 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Curative | FORMALDEHYDE 10% Approved UseDrying agent for pre and post surgical removal of warts, or for non-surgical laser treatment of warts where dryness is required. Safeguards against offensive odor and dries excessive moisture of feet. Not to be used in patients known to be sensitive to any of the ingredients in this product. |
PubMed
| Title | Date | PubMed |
|---|---|---|
| NAD-linked, factor-dependent formaldehyde dehydrogenase or trimeric, zinc-containing, long-chain alcohol dehydrogenase from Amycolatopsis methanolica. | 1992 Jun 1 |
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| Crystal structure of an electron-transfer complex between methylamine dehydrogenase and amicyanin. | 1992 Jun 2 |
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| The L-arginine/nitric oxide/cyclic-GMP pathway apparently mediates the peripheral antihyperalgesic action of fentanyl in rats. | 2003 Dec |
|
| Potentiation of allergic bronchoconstriction by repeated exposure to formaldehyde in guinea-pigs in vivo. | 2003 Dec |
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| [Scleroderma and occupational risk factors: a case-control study]. | 2003 Jul-Sep |
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| Systemic contact dermatitis of the eyelids caused by formaldehyde derived from aspartame? | 2003 Nov |
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| [Effects of formaldehyde on germ cells of male mice]. | 2003 Nov |
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| Inhalation of low-level formaldehyde enhances nerve growth factor production in the hippocampus of mice. | 2004 |
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| Multiple formaldehyde oxidation/detoxification pathways in Burkholderia fungorum LB400. | 2004 Apr |
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| Differential immunogenic and neurogenic inflammatory responses in an allergic mouse model exposed to low levels of formaldehyde. | 2004 Apr 1 |
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| Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. | 2004 Apr 26 |
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| Diagnosis and treatment of dermatitis due to formaldehyde resins in clothing. | 2004 Dec |
|
| A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1. | 2004 Dec |
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| GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats. | 2004 Dec |
|
| Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. | 2004 Dec 29 |
|
| Protein associated with Myc (PAM) is involved in spinal nociceptive processing. | 2004 Feb |
|
| Reproducibility of patch tests: comparison of identical test allergens from different commercial sources. | 2004 Jan |
|
| Effect of prolonged exposure to low concentrations of formaldehyde on the corticotropin releasing hormone neurons in the hypothalamus and adrenocorticotropic hormone cells in the pituitary gland in female mice. | 2004 Jul 2 |
|
| Allergic contact sensitivity in elderly patients. | 2004 Jun |
|
| Hepatocyte proliferation in chronic hepatitis C: correlation with degree of liver disease and serum alpha-fetoprotein. | 2004 Jun |
|
| Biodegradation of alachlor by soil streptomycetes. | 2004 Jun |
|
| Mortality from solid cancers among workers in formaldehyde industries. | 2004 Jun 15 |
|
| Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdeydes unsaturated sesquiterpenes polygodial and drimanial in rats. | 2004 Mar |
|
| [Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations]. | 2004 May |
|
| Investigations into the antinociceptive activity of Sapindus trifoliatus in various pain models. | 2004 May |
|
| Long-term exposure to low levels of formaldehyde increases the number of tyrosine hydroxylase-immunopositive periglomerular cells in mouse main olfactory bulb. | 2004 May 8 |
|
| The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity. | 2004 Oct |
|
| [Allergy to formaldehyde]. | 2004 Sep |
|
| Protein cross-linkage induced by formaldehyde derived from semicarbazide-sensitive amine oxidase-mediated deamination of methylamine. | 2004 Sep |
|
| Use of the platelet reactivity index by Grotemeyer, platelet function analyzer, and retention test Homburg to monitor therapy with antiplatelet drugs. | 2005 |
|
| Transcriptomic analysis of F344 rat nasal epithelium suggests that the lack of carcinogenic response to glutaraldehyde is due to its greater toxicity compared to formaldehyde. | 2005 |
|
| Effect of formaldehyde gas exposure in a murine allergic contact hypersensitivity model. | 2005 |
|
| Supratentorial primitive neuroectodermal tumours of the brain: multidirectional differentiation does not influence prognosis. A clinicopathological report of 18 patients. | 2005 Apr |
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| Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. | 2005 Apr |
|
| Protective effect of NAC on formaldehyde-containing-ZOE-based root-canal-sealers-induced cyclooxygenase-2 expression and cytotoxicity in human osteoblastic cells. | 2005 Aug |
|
| Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity. | 2005 Feb |
|
| The role of intracellularly released formaldehyde and butyric acid in the anticancer activity of acyloxyalkyl esters. | 2005 Feb 24 |
|
| An ecological study of the association of environmental chemicals on breast cancer incidence in Texas. | 2005 Jul |
|
| p53 protein expression in chronic hepatitis C; effect of interferon alpha 2b therapy. | 2005 Jul-Aug |
|
| Contact sensitivity to preservatives in Turkey. | 2005 Jun |
|
| Hypothalamo-pituitary-adrenal gland axis in mice inhaling toluene prior to low-level long-term exposure to formaldehyde. | 2005 Mar |
|
| Redox imbalance induced by contact sensitizers triggers the maturation of dendritic cells. | 2005 Mar |
|
| [Study on differential display genes of tolerant-damage of MRC-5 induced by formaldehyde of low dose]. | 2005 May |
|
| Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: biochemical and histological studies. | 2005 May |
|
| The interaction of trimethylamine dehydrogenase and electron-transferring flavoprotein. | 2005 May 27 |
|
| Postmortem distribution of sildenafil in histological material. | 2005 May-Jun |
|
| Thrombotic thrombocytopenic purpura causing rapid unexpected death: value of CD61 immunohistochemical staining in diagnosis. | 2005 May-Jun |
|
| Detection of chlamydial bodies and antigens in the central nervous system of patients with multiple sclerosis. | 2005 Oct 1 |
|
| Identification of N,N-dimethylamphetamine formed by methylation of methamphetamine in formalin-fixed liver tissue by multistage mass spectrometry. | 2006 Mar 10 |
|
| Protective effects of omega-3 essential fatty acids against formaldehyde-induced neuronal damage in prefrontal cortex of rats. | 2006 May-Jun |
Sample Use Guides
Formaldehyde 10% solution is applied topically once a day to affected areas.
Route of Administration:
Topical
Human lymphoblasts were exposed in vitro to various concentrations of formaldehyde (HCHO) in single and multiple treatment regimens to determine relative mutagenic efficiency. HCHO treatment resulted in a significant nonlinear increase in DNA-protein crosslinks at concentrations greater than 50 uM X 2 h, which correlated with the onset of significant toxicity in this cell line.
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68716
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CHEMBL2108542
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DTXSID00202946
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m413
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C175194
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54531-52-1
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727
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300000036838
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8B8GHO5O27
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9006-68-2
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SUPERSEDED |
SUBSTANCE RECORD
