MORPHOLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H9NO
Molecular Weight	87.1204
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1COCCN1

InChI

InChIKey=YNAVUWVOSKDBBP-UHFFFAOYSA-N

InChI=1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/international/morpholine-salicylate.html

Morpholine salicylate is a derivative of salicylic acid. It is a non-steroidal anti-inflammatory drug and was marketed under a tradename Retarcyl, Dolical and Deposal.

Approval Year

PubMed

Title	Date	PubMed
Inhibition of RNA synthesis in vitro and cell growth by anthracycline antibiotics.	2001	11845988
Final report on the safety assessment of Cetethyl Morpholinium Ethosulfate.	2001	11766137
Learning the language of cell-cell communication through connexin channels.	2001	11737941
A cytochrome P450 and a ferredoxin isolated from Mycobacterium sp. strain HE5 after growth on morpholine.	2001 Aug	11549020
Reactions with pyrrolidine-2,4-diones, Part 4: Synthesis of some 3-substituted 1,5-diphenylpyrrolidine-2,4-diones as potential antimicrobial, anti-HIV-1 and antineoplastic agents.	2001 Dec	11802654
Morpholinium 2-chloro-4-nitrobenzoate, 2-chloro-5-nitrobenzoate and 4-chloro-3-nitrobenzoate.	2001 Dec	11740114
O-Phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity.	2001 Dec 6	11728191
In situ 1H NMR study of the biodegradation of xenobiotics: application to heterocyclic compounds.	2001 Jan-Feb	11548745
Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning.	2001 Jul	11703928
[Effect of thiotriazoline on the blood supply and oxygen balance in the brain in models of exposure to general vibration].	2001 Mar-Apr	11548445
Shellac formulations to reduce epiphytic survival of coliform bacteria on citrus fruit postharvest.	2001 Nov	11726155
Expression of c-myc is not critical for cell proliferation in established human leukemia lines.	2001 Nov 16	11734062
Inhibition of Vesivirus infections in mammalian tissue culture with antisense morpholino oligomers.	2001 Oct	11763348
trans-2,4,4,6,8,8-Hexamorpholino-2,6-bis(n-propylamino)cyclo-2lambda5,4lambda5,6lambda5,8lambda5-tetraphosphazatetraene.	2001 Oct	11600795
Kermit, a frizzled interacting protein, regulates frizzled 3 signaling in neural crest development.	2001 Oct	11585793
Polar nitrogen compounds and their behaviour in the drinking water treatment process.	2001 Oct	11561612
In vitro selection of allosteric ribozymes: theory and experimental validation.	2001 Oct 5	11580234
Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo.	2001 Sep	11566861
Early embryonic expression of a LIM-homeobox gene Cs-lhx3 is downstream of beta-catenin and responsible for the endoderm differentiation in Ciona savignyi embryos.	2001 Sep	11566860
XMeis3 protein activity is required for proper hindbrain patterning in Xenopus laevis embryos.	2001 Sep	11566848
Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development.	2001 Sep	11520667
A novel sox gene, 226D7, acts downstream of Nodal signaling to specify endoderm precursors in zebrafish.	2001 Sep	11520661
The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish.	2001 Sep 15	11562356
Kinetics and mechanisms of the reactions of 3-methoxyphenyl, 3-chlorophenyl, and 4-cyanophenyl 4-nitrophenyl thionocarbonates with alicyclic amines.	2001 Sep 7	11529741
2001: a mouse genome odyssey.	2002	11864368
Adamantyl tenocyclidines--adjuvant therapy in poisoning with organophosphorus compounds and carbamates.	2002 Apr	11967623
Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats.	2002 Apr	11948540
Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis.	2002 Apr	11934867
LvDelta is a mesoderm-inducing signal in the sea urchin embryo and can endow blastomeres with organizer-like properties.	2002 Apr	11934860
Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro.	2002 Apr	11893932
Thiourea derivatives and their nickel(II) and platinum(II) complexes: antifungal activity.	2002 Apr 10	11931966
The IGF pathway regulates head formation by inhibiting Wnt signaling in Xenopus.	2002 Apr 15	11944947
Axial protocadherin is a mediator of prenotochord cell sorting in Xenopus.	2002 Apr 15	11944936
Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.	2002 Feb	11880036
Low density lipoprotein receptor-related protein mediates apolipoprotein E inhibition of smooth muscle cell migration.	2002 Feb 8	11739389
Conformationally restrained analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2',5'-morpholines].	2002 Jan	11841871
The transcription factor Sox9 is required for cranial neural crest development in Xenopus.	2002 Jan	11807034
Novel piperidinyloxy oxazolidinone antibacterial agents. Diversification of the N-Substituent.	2002 Jul	11983532
Multiple functions of a Zic-like gene in the differentiation of notochord, central nervous system and muscle in Ciona savignyi embryos.	2002 Jun	12015299
Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.	2002 Jun	11937330
A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo.	2002 Jun 1	12027441
Multiple interactions between maternally-activated signalling pathways control Xenopus nodal-related genes.	2002 Mar	11934150
In vitro studies indicate that acid catalysed generation of N-nitrosocompounds from dietary nitrate will be maximal at the gastro-oesophageal junction and cardia.	2002 Mar	11916186
macho-1-Related genes in Ciona embryos.	2002 Mar	11914940
Tumor pretargeting in mice using (99m)Tc-labeled morpholino, a DNA analog.	2002 Mar	11884499
her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis.	2002 Mar	11874913
The planar polarity gene strabismus regulates convergent extension movements in Xenopus.	2002 Mar 1	11867525
Relationship between lipophilicity and antitumor activity of molecule library of Mannich ketones determined by high-performance liquid chromatography, clogP calculation and cytotoxicity test.	2002 Mar 5	11888064
Fgf3 and Fgf8 are required together for formation of the otic placode and vesicle.	2002 May	11959820
Intramural coronary delivery of advanced antisense oligonucleotides reduces neointimal formation in the porcine stent restenosis model.	2002 May 15	12020498

Patents

Name

Type

Language

MORPHOLINE

Official Name

English

DIETHYLENE OXIMIDE

Common Name

English

NSC-9376

Code

English

MORPHOLINE [IARC]

Common Name

English

DIETHYLENE IMIDOXIDE

Common Name

English

MORPHOLINE [HSDB]

Common Name

English

MORPHOLINE [MI]

Common Name

English

MORPHOLINE [FCC]

Common Name

English

MORPHOLINE [INCI]

Common Name

English

TETRAHYDRO-2H-1,4-OXAZINE

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 172.235