Morpholine

Details

Stereochemistry	ACHIRAL
Molecular Formula	C4H9NO
Molecular Weight	87.1204
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1COCCN1

InChI

InChIKey=YNAVUWVOSKDBBP-UHFFFAOYSA-N

InChI=1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2

HIDE SMILES / InChI

Description
Sources: https://www.drugs.com/international/morpholine-salicylate.html

Morpholine salicylate is a derivative of salicylic acid. It is a non-steroidal anti-inflammatory drug and was marketed under a tradename Retarcyl, Dolical and Deposal.

Approval Year

PubMed

Title	Date	PubMed
Inhibition of RNA synthesis in vitro and cell growth by anthracycline antibiotics.	2001	11845988
Learning the language of cell-cell communication through connexin channels.	2001	11737941
An amphibian with ambition: a new role for Xenopus in the 21st century.	2001	11597339
The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineage and repressing melanogenesis in avian embryos.	2001 Apr	11262245
A cytochrome P450 and a ferredoxin isolated from Mycobacterium sp. strain HE5 after growth on morpholine.	2001 Aug	11549020
Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [(14)C]linezolid to healthy human subjects.	2001 Aug	11454733
Active repression of RAR signaling is required for head formation.	2001 Aug 15	11511542
X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor.	2001 Aug 30	11520201
Synthesis of Mannich bases of some 2,5-disubstituted 4-thiazolidinones and evaluation of their antimicrobial activities.	2001 Feb	11268772
TBP is not universally required for zygotic RNA polymerase II transcription in zebrafish.	2001 Feb 20	11250159
In situ 1H NMR study of the biodegradation of xenobiotics: application to heterocyclic compounds.	2001 Jan-Feb	11548745
A morpholino phenocopy of the colourless mutant.	2001 Jul	11477705
Morpholino phenocopies of sqt, oep, and ntl mutations.	2001 Jul	11477701
Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations.	2001 Jul	11477698
Comparison of morpholino based translational inhibition during the development of Xenopus laevis and Xenopus tropicalis.	2001 Jul	11477685
Cyclin E morpholino delays embryogenesis in Xenopus.	2001 Jul	11477684
Action of morpholinos in Ciona embryos.	2001 Jul	11477683
Redox-induced terpyridyl substitution in the Os(VI)-hydrazido complex, trans-[Os(VI)(tpy)(Cl)(2)(NN(CH(2))(4)O)](2+).	2001 Jul 30	11466041
The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish.	2001 Jun	11493559
sprouty4 acts in vivo as a feedback-induced antagonist of FGF signaling in zebrafish.	2001 Jun	11493538
Quantitation of intracellular concentration of a delivered morpholino oligomer by capillary electrophoresis-laser- induced fluorescence: correlation with upregulation of luciferase gene expression.	2001 Jun 1	11373071
Synthesis, characterization, and ligand exchange studies of W(6)S(8)L(6) cluster compounds.	2001 Jun 4	11375677
Linezolid: an oxazolidinone antimicrobial agent.	2001 Mar	11318073
[Effect of thiotriazoline on the blood supply and oxygen balance in the brain in models of exposure to general vibration].	2001 Mar-Apr	11548445
trans-2,4,4,6,8,8-Hexamorpholino-2,6-bis(n-propylamino)cyclo-2lambda5,4lambda5,6lambda5,8lambda5-tetraphosphazatetraene.	2001 Oct	11600795
Polar nitrogen compounds and their behaviour in the drinking water treatment process.	2001 Oct	11561612
In vitro selection of allosteric ribozymes: theory and experimental validation.	2001 Oct 5	11580234
Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo.	2001 Sep	11566861
Tight transcriptional control of the ETS domain factors Erm and Pea3 by Fgf signaling during early zebrafish development.	2001 Sep	11520667
A novel sox gene, 226D7, acts downstream of Nodal signaling to specify endoderm precursors in zebrafish.	2001 Sep	11520661
Abnormal neural crest cell migration after the in vivo knockdown of tenascin-C expression with morpholino antisense oligonucleotides.	2001 Sep	11507773
Kinetics and mechanisms of the reactions of 3-methoxyphenyl, 3-chlorophenyl, and 4-cyanophenyl 4-nitrophenyl thionocarbonates with alicyclic amines.	2001 Sep 7	11529741
2001: a mouse genome odyssey.	2002	11864368
Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats.	2002 Apr	11948540
Expression of ROCK-1 in human pancreatic cancer: its down-regulation by morpholino oligo antisense can reduce the migration of pancreatic cancer cells in vitro.	2002 Apr	11893932
Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes.	2002 Feb	11880036
Conformationally restrained analogues of sympathomimetic catecholamines. Synthesis and adrenergic activity of 5,6- and 6,7-dihydroxy-3,4-dihydrospiro[naphthalen-1(2H)-2',5'-morpholines].	2002 Jan	11841871
Multiple functions of a Zic-like gene in the differentiation of notochord, central nervous system and muscle in Ciona savignyi embryos.	2002 Jun	12015299
A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo.	2002 Jun 1	12027441
In vitro studies indicate that acid catalysed generation of N-nitrosocompounds from dietary nitrate will be maximal at the gastro-oesophageal junction and cardia.	2002 Mar	11916186
Tumor pretargeting in mice using (99m)Tc-labeled morpholino, a DNA analog.	2002 Mar	11884499
her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesis.	2002 Mar	11874913
Relationship between lipophilicity and antitumor activity of molecule library of Mannich ketones determined by high-performance liquid chromatography, clogP calculation and cytotoxicity test.	2002 Mar 5	11888064

Patents

Name

Type

Language

Morpholine

Official Name

English

NSC-9376

Preferred Name

English

Diethylene oximide

Common Name

English

Morpholine [IARC]

Common Name

English

Diethylene imidoxide

Common Name

English

Morpholine [HSDB]

Common Name

English

Morpholine [MI]

Common Name

English

Morpholine [FCC]

Common Name

English

Tetrahydro-2H-1,4-oxazine

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 172.235