U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C8H8Cl3O3PS
Molecular Weight 321.545
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of RONNEL

SMILES

COP(=S)(OC)OC1=C(Cl)C=C(Cl)C(Cl)=C1

InChI

InChIKey=JHJOOSLFWRRSGU-UHFFFAOYSA-N
InChI=1S/C8H8Cl3O3PS/c1-12-15(16,13-2)14-8-4-6(10)5(9)3-7(8)11/h3-4H,1-2H3

HIDE SMILES / InChI

Description

Ronnel [0,0-dimethyl 0-(2,4,5-trichlorophenyl) phosphorothioate] is an organophosphate pesticide with growth-promoting properties. It was used to prevent and cure the parasitic in veterinary medicine. Biocidal (toxic to all animal life in differing degrees) by its action as a cholinesterase inhibitor.

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
Curative
Preclinical
Unknown

Approved Use

Unknown
Preventing
Approved
8583
Ectoral

Approved Use

Oral administration to livestock controls cattle grub, lice, horn fly, face fly, screwworm, ticks, sheep ked, and wool maggot

Launch Date

1960
PubMed

PubMed

TitleDatePubMed
Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism.
2008-04
Apparent acaridal dermatitis in a C57BL/6 Nya mouse colony.
1976-10
Patents

Patents

US4211775
1

Sample Use Guides

In Vivo Use Guide
Curator's Comment: Topical application in dogs has being shown for generalized demodicosis
Catle: Steers were fed 0, 2, 4 and 8 mg ronnel/kg body weight daily in a Latin square arrangement of treatments with five 28-d periods.
Route of Administration: Oral
In Vitro Use Guide
Ronnel in concentrations of 1.24, 6.22, 49.7 uM decreased T4 to T3 conversion in liver and kidney from Angus steers 46 and 45, 51 and 72, and 78 and 95%, respectively.
Name Type Language
FENCLOFOS
INN  
INN  
Preferred Name English
RONNEL
GREEN BOOK   HSDB   MI   USAN  
USAN  
Official Name English
FENCHLORPHOS [ISO]
Common Name English
NSC-8926
Code English
FENCHLORPHOS
ISO  
Common Name English
BLITEX
Brand Name English
O,O-Dimethyl O-(2,4,5-trichlorophenyl) phosphorothioate
Systematic Name English
RONNEL [GREEN BOOK]
Common Name English
RONNEL [USAN]
Common Name English
REMELT
Brand Name English
TRICHLOROMETAPHOS
Common Name English
FENCLORFOS
Common Name English
ENT 23,284
Code English
NANCHOR
Brand Name English
ENT-23284
Code English
ECTORAL
Brand Name English
FENCLORVUR
Brand Name English
O,O-DIMETHYL O-2,4,5-TRICHLOROPHENYL PHOSPHOROTHIOATE
Common Name English
RONNEL [MI]
Common Name English
GESEKTIN K
Brand Name English
KORLANE
Brand Name English
ETROLENE
Brand Name English
TROLENE
Brand Name English
PHOSPHOROTHIOIC ACID, O,O-DIMETHYL O-(2,4,5-TRICHLOROPHENYL) ESTER
Common Name English
OMS-123
Code English
VIOZENE
Brand Name English
NANKOR
Brand Name English
RONNEL [HSDB]
Common Name English
ROVAN
Brand Name English
TRICHLORMETAPHOS
Common Name English
fenclofos [INN]
Common Name English
KORLAN
Brand Name English
DERMAFOS
Brand Name English
TROLEN
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C737
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
EPA PESTICIDE CODE 58301
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
Code System Code Type Description
DRUG BANK
DB11456
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
ChEMBL
CHEMBL1871418
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
FDA UNII
89RAG7SB3B
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
HSDB
667
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
ECHA (EC/EINECS)
206-082-6
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
CAS
299-84-3
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
MERCK INDEX
m9657
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY Merck Index
EVMPD
SUB07550MIG
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
PUBCHEM
9298
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
EPA CompTox
DTXSID2034885
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
SMS_ID
100000081248
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
NCI_THESAURUS
C76879
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
INN
2855
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
NSC
8926
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
ALANWOOD
fenchlorphos
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
MESH
C091929
Created by admin on Wed Apr 02 09:13:37 GMT 2025 , Edited by admin on Wed Apr 02 09:13:37 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of RONNEL
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966