SUMAROTENE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C24H30O2S
Molecular Weight	382.559
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C\C(=C/C1=CC=C(C=C1)S(C)(=O)=O)C2=CC3=C(C=C2)C(C)(C)CCC3(C)C

InChI

InChIKey=AUCWKKVIBKHRED-BMRADRMJSA-N

InChI=1S/C24H30O2S/c1-17(15-18-7-10-20(11-8-18)27(6,25)26)19-9-12-21-22(16-19)24(4,5)14-13-23(21,2)3/h7-12,15-16H,13-14H2,1-6H3/b17-15+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2061443 | https://www.ncbi.nlm.nih.gov/pubmed/1500445

Sumarotene (also known as Ro 14-9706) is a third-generation retinoid developed by Hoffmann-La Roche, F., und Co. A.-G., as a topical dermatologic agent for the repair of photodamage, antikeratinization, and antiproliferation. Sumarotene shows activity in standard preclinical and pharmacologic models of repair of photodamage, antikeratinization, and antiproliferation. In clinical trials, Sumarotene effectively decreases the number of actinic keratoses. Sumarotene is well-tolerated and most patients have only slight or absent local inflammation.

Originator

Approval Year

PubMed

Title	Date	PubMed
Topical treatment of multiple actinic keratoses of the face with arotinoid methyl sulfone (Ro 14-9706) cream versus tretinoin cream: a double-blind, comparative study.	1991 Mar	2061443

Patents

Sample Use Guides

In Vivo Use Guide

twice daily for 16 weeks as a 0.05% cream

Route of Administration: Topical

Name

Type

Language

SUMAROTENE

Official Name

English

sumarotene [INN]

Common Name

English

SUMAROTENE [USAN]

Common Name

English

RO 14-9706/000

Code

English

RO-14-9706/000

Code

English

RO-149706000

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C938