TINAZOLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C11H11N3S
Molecular Weight	217.29
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C1CN=C(N1)SC2=CNC3=C2C=CC=C3

InChI

InChIKey=JENBDJGHNIOHAJ-UHFFFAOYSA-N

InChI=1S/C11H11N3S/c1-2-4-9-8(3-1)10(7-14-9)15-11-12-5-6-13-11/h1-4,7,14H,5-6H2,(H,12,13)

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6197522 | https://www.ncbi.nlm.nih.gov/pubmed/7333649

Tinazoline is an imidazole derivative patented by Ciba-Geigy A.-G. as vasoconstrictors, particularly as nasal decongestants in the treatment of common cold. Tinazoline showing potent and long-acting vasoconstrictor activity on several vascular beds in dogs, guinea-pigs, cats, and rabbits. The vasoconstrictor effect has been shown in animals to be due to a stimulation of the 1-adrenoceptors and the compound does not exhibit any B-adrenoceptor agonist activity.

Approval Year

PubMed

Title	Date	PubMed
Tolerability profile of a new nasal decongestant--tinazoline hydrochloride (Go-7996 B): open and double-blind studies in human male volunteers.	1983-07	6197522
[Injections for non-suppurative bursitis: obliteration with varsyl].	1951-08-25	14882075

Patents

Sample Use Guides

In Vivo Use Guide

0.04% and 0.08% concentrations 2-3 drops per nostril

Route of Administration: Nasal

Name

Type

Language

tinazoline [INN]

Preferred Name

English

TINAZOLINE

Official Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29713