ITRIGLUMIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C33H38N2O4
Molecular Weight	526.6658
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=CC(C)=C(NC(=O)C[C@H](CC(O)=O)C2=C3C=CC=CC3=CC=C2)C(=C1)C(=O)N4CCC5(CCCC5)CC4

InChI

InChIKey=MFOOVZCXWVAWOV-RUZDIDTESA-N

InChI=1S/C33H38N2O4/c1-22-18-23(2)31(28(19-22)32(39)35-16-14-33(15-17-35)12-5-6-13-33)34-29(36)20-25(21-30(37)38)27-11-7-9-24-8-3-4-10-26(24)27/h3-4,7-11,18-19,25H,5-6,12-17,20-21H2,1-2H3,(H,34,36)(H,37,38)/t25-/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67116183 | https://www.ncbi.nlm.nih.gov/pubmed/10204685 | https://www.ncbi.nlm.nih.gov/pubmed/12921485

ITRIGLUMIDE, an anthranilic acid derivative, is a cholecystokinin B receptor antagonist.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cholecystokinin B receptor 9 Target ID: CHEMBL298 Sources: https://www.ncbi.nlm.nih.gov/pubmed/10204685	Antagonist 2778		2.3 nM [IC50]

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vitro Use Guide

Cytosolic Ca2+ elevation in rabbit parietal cells induced by gastrin (50 nM) was blocked by itriglumide (CR 2945) with an IC50 value of 5.9 nM.

Name

Type

Language

ITRIGLUMIDE

Official Name

English

itriglumide [INN]

Common Name

English

(+)-CR-2945

Code

English

(R)-2'-(8-AZASPIRO(4,5)DEC-8-YLCARBONYL)-4',6'-DIMETHYL-3-(1-NAPHTHYL)GLUTARANILIC ACID

Systematic Name

English

CR-2945

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29701