Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H26Cl2N4 |
| Molecular Weight | 417.375 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCC(CCC)N1CCN2N=C(C3=C2C1=CC(C)=N3)C4=CC=C(Cl)C=C4Cl
InChI
InChIKey=AKLMUGFDGONMAA-UHFFFAOYSA-N
InChI=1S/C22H26Cl2N4/c1-4-6-16(7-5-2)27-10-11-28-22-19(27)12-14(3)25-21(22)20(26-28)17-9-8-15(23)13-18(17)24/h8-9,12-13,16H,4-7,10-11H2,1-3H3
Approval Year
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Code | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
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874OEY3JEJ
Created by
admin on Tue Apr 01 17:49:07 GMT 2025 , Edited by admin on Tue Apr 01 17:49:07 GMT 2025
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PRIMARY | |||
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268545-87-5
Created by
admin on Tue Apr 01 17:49:07 GMT 2025 , Edited by admin on Tue Apr 01 17:49:07 GMT 2025
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9888194
Created by
admin on Tue Apr 01 17:49:07 GMT 2025 , Edited by admin on Tue Apr 01 17:49:07 GMT 2025
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NBI-34041
Created by
admin on Tue Apr 01 17:49:07 GMT 2025 , Edited by admin on Tue Apr 01 17:49:07 GMT 2025
|
PRIMARY | Description: NBI-34041 is potent and high-affinity CRF1 receptor antagonist. NBI-34041 is safety and efficacy in attenuating elevated stress response. NBI-34041 is effective in reducing endocrine responses to pharmacological and behavioral challenge mediated by CRF(1) receptors. NBI-34041 is safe and does not impair basal regulation of the HPA system but improves resistance against psychosocial stress. NBI-34041 demonstrates that inhibition of the CRF system is a promising target for drug development against depression and anxiety disorders. (last updated: 3/8/2016). |
ACTIVE MOIETY
