U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C39H48N4O5
Molecular Weight 652.8222
Optical Activity UNSPECIFIED
Defined Stereocenters 5 / 5
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of L-756423

SMILES

CC(C)(C)NC(=O)[C@@H]1CN(CC2=CC3=C(O2)C=CC=C3)CCN1C[C@@H](O)C[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H]5[C@H](O)CC6=C5C=CC=C6

InChI

InChIKey=AOMZDQMIOCTPQP-QHQMVRJISA-N
InChI=1S/C39H48N4O5/c1-39(2,3)41-38(47)33-25-42(24-31-21-28-14-8-10-16-35(28)48-31)17-18-43(33)23-30(44)20-29(19-26-11-5-4-6-12-26)37(46)40-36-32-15-9-7-13-27(32)22-34(36)45/h4-16,21,29-30,33-34,36,44-45H,17-20,22-25H2,1-3H3,(H,40,46)(H,41,47)/t29-,30+,33+,34-,36+/m1/s1

HIDE SMILES / InChI

Approval Year

PubMed

PubMed

TitleDatePubMed
Determination of L-756 423, a novel HIV protease inhibitor, in human plasma and urine using high-performance liquid chromatography with fluorescence detection.
1999 Sep 24
Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.
2000 Sep 7
Patents

Patents

Name Type Language
L-756423
Code English
MK-944A
Code English
D-ERYTHRO-PENTONAMIDE, 5-((2S)-4-(2-BENZOFURANYLMETHYL)-2-(((1,1-DIMETHYLETHYL)AMINO)CARBONYL)-1-PIPERAZINYL)-2,3,5-TRIDEOXY-N-((1S,2R)-2,3-DIHYDRO-2-HYDROXY-1H-INDEN-1-YL)-2-(PHENYLMETHYL)-
Systematic Name English
Code System Code Type Description
PUBCHEM
5481481
Created by admin on Sat Dec 16 08:18:28 UTC 2023 , Edited by admin on Sat Dec 16 08:18:28 UTC 2023
PRIMARY
CAS
216863-66-0
Created by admin on Sat Dec 16 08:18:28 UTC 2023 , Edited by admin on Sat Dec 16 08:18:28 UTC 2023
PRIMARY
DRUG BANK
DB02009
Created by admin on Sat Dec 16 08:18:28 UTC 2023 , Edited by admin on Sat Dec 16 08:18:28 UTC 2023
PRIMARY
FDA UNII
862SGU1BRL
Created by admin on Sat Dec 16 08:18:28 UTC 2023 , Edited by admin on Sat Dec 16 08:18:28 UTC 2023
PRIMARY