GANAPLACIDE

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H23F2N5O
Molecular Weight	411.4477
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1(C)N(CCN2C(NC3=CC=C(F)C=C3)=C(N=C12)C4=CC=C(F)C=C4)C(=O)CN

InChI

InChIKey=BUPRVECGWBHCQV-UHFFFAOYSA-N

InChI=1S/C22H23F2N5O/c1-22(2)21-27-19(14-3-5-15(23)6-4-14)20(26-17-9-7-16(24)8-10-17)28(21)11-12-29(22)18(30)13-25/h3-10,26H,11-13,25H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/30223692 | https://www.ncbi.nlm.nih.gov/pubmed/29802605 | https://www.ncbi.nlm.nih.gov/pubmed/29304859

GNF-156 (ganaplacide or KAF-156) is an antimalarial agent that is part of the imidazolopiperazine family. It exerts activity against pre-erythrocytic liver stages, asexual and sexual blood stages. An improvement compared to existing antimalarial drug combinations is that this compound shows promising single-dose antimalarial activity, and no serious safety and tolerability concerns in humans are known so far. Phase II clinical trials have been completed for GNF-156. Its potential is also being investigated in combination with lumefantrine (an aryl-amino alcohol) in LUM-KAF156.

Approval Year

Name

Type

Language

KAF-156

Preferred Name

English

GANAPLACIDE

Official Name

English

Ganaplacide [WHO-DD]

Common Name

English

ETHANONE, 2-AMINO-1-(2-(4-FLUOROPHENYL)-3-((4-FLUOROPHENYL)AMINO)-5,6-DIHYDRO-8,8-DIMETHYLIMIDAZO(1,2-A)PYRAZIN-7(8H)-YL)-

Systematic Name

English

ganaplacide [INN]

Common Name

English

GNF 156

Code

English

2-AMINO-1-(2-(4-FLUOROPHENYL)-3-((4-FLUOROPHENYL)AMINO)-5,6-DIHYDRO-8,8-DIMETHYLIMIDAZO(1,2-A)PYRAZIN-7(8H)-YL)ETHANONE

Systematic Name

English

GNF-156

Code

English

KAF156

Code

English

KAF 156

Code

English

Classification Tree Code System Code

FDA ORPHAN DRUG

895622