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Details

Stereochemistry ABSOLUTE
Molecular Formula 2C11H23N2OS.O.V
Molecular Weight 529.697
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge -4

SHOW SMILES / InChI
Structure of NAGLIVAN

SMILES

[O--].[V].[H][C@](N)(C[S-])C(=O)NCCCCCCCC.[H][C@](N)(C[S-])C(=O)NCCCCCCCC

InChI

InChIKey=PTNIVTYIODVYLK-XFMZQWNHSA-L
InChI=1S/2C11H24N2OS.O.V/c2*1-2-3-4-5-6-7-8-13-11(14)10(12)9-15;;/h2*10,15H,2-9,12H2,1H3,(H,13,14);;/q;;-2;/p-2/t2*10-;;/m00../s1

HIDE SMILES / InChI
Naglivan [PMD 501, vanadeine] is a vanadyl organometallic agent, in the preclinical phase of development in France, with Pan Medica, as an orally-active drug for the treatment of diabetes mellitus. Naglivan is an orally effective form of vanadyl with an oral potency 7.6 times greater than that of vanadyl sulfate (minimum effective dose: 0.06 mmol vanadium.kg-1.day-1) as compared to vanadyl sulfate (0.46 mmol vanadium.kg-1.day-1). The lack of incidence of diarrhea in either control or diabetic animals demonstrates that naglivan could be a more therapeutically desirable form of vanadyl.

Approval Year

PubMed

PubMed

TitleDatePubMed
In vivo antidiabetic actions of naglivan, an organic vanadyl compound in streptozotocin-induced diabetes.
1993 May

Sample Use Guides

The antidiabetic effects of naglivan in rats made diabetic with streptozotocin (55 mg/kg, i.v.) were tested. Four days after the streptozotocin injection, one diabetic group (DVI) and a control group (CV) were treated with naglivan (50 mg/kg/day, equivalent to 0.06 mmol vanadium/kg/day) by oral gavage.
Route of Administration: Oral
Name Type Language
NAGLIVAN
INN  
INN  
Official Name English
OXOVANADIUM(2+), (2R)-2-AMINO-3-(OCTYLAMINO)-3-OXOPROPANE-1-THIOLATE
Systematic Name English
naglivan [INN]
Common Name English
Code System Code Type Description
EVMPD
SUB09135MIG
Created by admin on Sat Dec 16 08:29:49 GMT 2023 , Edited by admin on Sat Dec 16 08:29:49 GMT 2023
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FDA UNII
85E1SB2UXO
Created by admin on Sat Dec 16 08:29:49 GMT 2023 , Edited by admin on Sat Dec 16 08:29:49 GMT 2023
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SMS_ID
100000084459
Created by admin on Sat Dec 16 08:29:49 GMT 2023 , Edited by admin on Sat Dec 16 08:29:49 GMT 2023
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NCI_THESAURUS
C175155
Created by admin on Sat Dec 16 08:29:49 GMT 2023 , Edited by admin on Sat Dec 16 08:29:49 GMT 2023
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CAS
122575-28-4
Created by admin on Sat Dec 16 08:29:49 GMT 2023 , Edited by admin on Sat Dec 16 08:29:49 GMT 2023
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PUBCHEM
155491340
Created by admin on Sat Dec 16 08:29:49 GMT 2023 , Edited by admin on Sat Dec 16 08:29:49 GMT 2023
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EPA CompTox
DTXSID10153652
Created by admin on Sat Dec 16 08:29:49 GMT 2023 , Edited by admin on Sat Dec 16 08:29:49 GMT 2023
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INN
6789
Created by admin on Sat Dec 16 08:29:49 GMT 2023 , Edited by admin on Sat Dec 16 08:29:49 GMT 2023
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