Details
Stereochemistry | ACHIRAL |
Molecular Formula | C25H46N.Cl |
Molecular Weight | 396.092 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].CCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1
InChI
InChIKey=SXPWTBGAZSPLHA-UHFFFAOYSA-M
InChI=1S/C25H46N.ClH/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-23-26(2,3)24-25-21-18-17-19-22-25;/h17-19,21-22H,4-16,20,23-24H2,1-3H3;1H/q+1;/p-1
Cetalkonium chloride is a cationic quaternary ammonium surfactant, which is used for the treatment of mouth ulcers and sores (Bonjela trade name). It is also serves as an excipient for the purpose of long-term stabilization of ciclosporin ocular formulation, used in patients with dry eye syndrom (Ikervis trade name). The antibacterial properties of cetalkonium can be explained by its detergent character. Once applied, cetalkonium blocks the survival of biofilm forming bacterias.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Curative | BONJELA Approved UseFor the relief of pain, discomfort and inflammation caused by common mouth ulcers, cold sores, denture and sore spots, as well as mouth ulcers, and sore spots due to orthodontic devices. To help to fight minor mouth infection and aid healing of sore spots and ulcers due to dentures and orthodontic devices. |
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Inactive ingredient | IKERVIS Approved UseTreatment of severe keratitis in adult patients with dry eye disease, which has not improved despite treatment with tear substitutes. Launch Date1.42188478E12 |
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Primary | BONJELA Approved UseFor the relief of pain, discomfort and inflammation caused by common mouth ulcers, cold sores, denture and sore spots, as well as mouth ulcers, and sore spots due to orthodontic devices. To help to fight minor mouth infection and aid healing of sore spots and ulcers due to dentures and orthodontic devices. |
Doses
Dose | Population | Adverse events |
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0.1 % 1 times / day single, topical Studied dose Dose: 0.1 %, 1 times / day Route: topical Route: single Dose: 0.1 %, 1 times / day Sources: |
healthy, 28 to 55 years n = 8 Health Status: healthy Age Group: 28 to 55 years Sex: M+F Population Size: 8 Sources: |
Other AEs: Contact dermatitis... |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Contact dermatitis | 37.5% | 0.1 % 1 times / day single, topical Studied dose Dose: 0.1 %, 1 times / day Route: topical Route: single Dose: 0.1 %, 1 times / day Sources: |
healthy, 28 to 55 years n = 8 Health Status: healthy Age Group: 28 to 55 years Sex: M+F Population Size: 8 Sources: |
PubMed
Title | Date | PubMed |
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The trouble with teething--misdiagnosis and misuse of a topical medicament. | 2002 May |
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Investigation of the effects of wall adsorption of the visualization agent on baseline noise characteristics for indirect UV detection in capillary electrophoresis. | 2003 Sep |
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The synaptic vesicle proteome: a comparative study in membrane protein identification. | 2004 Oct |
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On the adsorption of cetyldimethylbenzylammonium chloride at the mercury/electrolyte solution interface. | 2005 May 15 |
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Mass spectrometrical identification of brain proteins including highly insoluble and transmembrane proteins. | 2006 Aug |
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Equilibrium studies for the adsorption of acid dye onto modified hectorite. | 2006 Aug 25 |
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Occupational contact dermatitis to Mikrobac Extra in 8 hospital cleaners. | 2006 Jan |
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Effect of deaeration on the adsorption of a mixture of cetyltrimethylammonium bromide and cetyldimethylbenzylammonium chloride at the mercury/electrolyte solution interface. | 2007 Jun 15 |
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Evaluation of two proteomics technologies used to screen the membrane proteomes of wild-type Corynebacterium glutamicum and an L-lysine-producing strain. | 2007 Oct |
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Reduction of quaternary ammonium-induced ocular surface toxicity by emulsions: an in vivo study in rabbits. | 2008 Jan 31 |
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Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. | 2008 Mar |
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Sorption of quaternary ammonium compounds to municipal sludge. | 2010 Apr |
Patents
Sample Use Guides
Massage one centimetre of the topical formulation (Bonjela) onto the affected area (mouth ulcers and sores) and leave at least 30 min in case of denture sores. In dry eye disease, the recommended dose is one drop of the ocular formulation (Ikervis) once daily to be applied to the affected eye(s) at bedtime.
Route of Administration:
Other
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24001405
Corneal human cells were treated with 0.005% cetalkonium chloride cationic oil-inwater nanoemulsion for 30 min. The emulsion was able to increase the pace of healing, as measured by the reduction of the size of the scraped area.
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EPA PESTICIDE CODE |
69108
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NCI_THESAURUS |
C28394
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Cetalkonium chloride
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ACTIVE MOIETY
SUBSTANCE RECORD