HEXETIDINE

US Previously Marketed

First approved in 1956

Details

Stereochemistry	MIXED
Molecular Formula	C21H45N3
Molecular Weight	339.6021
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1

InChI

InChIKey=DTOUUUZOYKYHEP-UHFFFAOYSA-N

InChI=1S/C21H45N3/c1-6-10-12-19(8-3)14-23-16-21(5,22)17-24(18-23)15-20(9-4)13-11-7-2/h19-20H,6-18,22H2,1-5H3

HIDE SMILES / InChI

Description
Sources: http://www.mccabespharmacy.com/oraldene-ice-mint-mouth-wash-200ml.html
Curator's Comment: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/11917691

Hexetidine is very safe oral antiseptic with broad antibacterial and antifungal activity in vivo and in vitro. It has local-anesthetics, astringent and deodorant activity. Also, it has very strong antiplac effects. Resistention of microorganisms on hexetidine is short and transient. These characteristics give important therapeutic role in treatment of oral infections. In the UK, hexetidine is the active ingredient in the medicated mouthwash branded Oraldene. Oraldene contains 0.1 g/100 ml of hexetidine. In Germany, hexetidine is used for vaginal antisepsis.

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Mouth ulcers 8 Sources: http://www.mccabespharmacy.com/oraldene-ice-mint-mouth-wash-200ml.html	Curative	Approved 8429	Oraldene Approved Use Unknown
Gingivitis 44 Sources: http://www.mccabespharmacy.com/oraldene-ice-mint-mouth-wash-200ml.html	Curative	Approved 8429	Oraldene Approved Use Unknown
Oral thrush 5 Sources: http://www.mccabespharmacy.com/oraldene-ice-mint-mouth-wash-200ml.html	Curative	Approved 8429	Oraldene Approved Use Unknown

Doses

Dose	Population	Adverse events
0.1 % 1 times / day multiple, oromucosal Dose: 0.1 %, 1 times / day Route: oromucosal Route: multiple Dose: 0.1 %, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/12834495	unhealthy, 38.2 years (range: 18–61 years) n = 46 Health Status: unhealthy Condition: supragingival plaque \| gingivitis Age Group: 38.2 years (range: 18–61 years) Sex: M+F Population Size: 46 Sources: https://pubmed.ncbi.nlm.nih.gov/12834495	Sources: https://pubmed.ncbi.nlm.nih.gov/12834495
10 mg 1 times / day multiple, vaginal Dose: 10 mg, 1 times / day Route: vaginal Route: multiple Dose: 10 mg, 1 times / day Sources: https://pubmed.ncbi.nlm.nih.gov/1773929	unhealthy n = 100 Health Status: unhealthy Sex: F Population Size: 100 Sources: https://pubmed.ncbi.nlm.nih.gov/1773929	Sources: https://pubmed.ncbi.nlm.nih.gov/1773929

Sourcing

Vendor/Aggregator	ID	URL
001 Chemical	DY522065	https://www.001chemical.com/chem/141-94-6
3B Scientific (Wuhan) Corp	3B3-023208	http://www.3bsc.com/index/pro_info.php?id=44285
AA Blocks	AA003QUE	https://www.aablocks.com/goods/Goods/detail?id=AA003QUE
AEchem Scientific Corp., USA	AE059285	https://www.aechemsc.com/info2_products/AE059285.php
AHH Chemical co.,ltd	MT-14721	http://www.ahhchemical.com/product/MT-14721.html
AK Scientific, Inc. (AKSCI)	X6883	http://www.aksci.com/item_detail.php?cat=X6883
Aaron Chemicals	AR003RM6	http://www.aaronchem.com/141-94-6
AbMole Bioscience	M5010	http://www.abmole.com/products/hexetidine.html
Alfa Aesar	L18699	https://www.alfa.com/en/catalog/L18699/
Ambeed	A560776	https://www.ambeed.com/products/141-94-6.html
BLD Pharm	BD133334	http://www.bldpharm.com/products/141-94-6.html
CSNpharm	CSN11149	https://www.csnpharm.com/products/hexetidine.html
Chem Scene	CS-4490	http://www.chemscene.com/141-94-6.html
ChemMol	49426750	http://www.chemmol.com/chemmol/49426750.html
Chemspace	CSSB00000039703	https://chem-space.com/CSSB00000039703
Clearsynth	CS-L-00161	https://www.clearsynth.com/en/CSL00161.html
DC Chemicals	DC37311	http://www.dcchemicals.com//product_show-Hexetidine.html
Debye Scientific	DB-042594	http://www.debyesci.com/cas_141-94-6.html
Finetech	FT-0627047	http://www.finetechnology-ind.com/prod/detail/pub/141-94-6.html
Hairui	HR123325	http://www.hairuichem.com/en/product/141-94-6.html
LGC Standards	DRE-A14202900AL-100	https://www.lgcstandards.com/US/en/p/DRE-A14202900AL-100
LGC Standards	DRE-C14202900	https://www.lgcstandards.com/US/en/p/DRE-C14202900
LGC Standards	MM0337.00	https://www.lgcstandards.com/US/en/p/MM0337.00
Lab Network	LN00241642	https://labnetwork.com/frontend-app/p/#!/moleculedetails/LN00241642
MedChem Express	HY-B0996	https://www.medchemexpress.com/Hexetidine.html
Molcore	MC522065	https://www.molcore.com/product/141-94-6
MuseChem	I001610	https://www.musechem.com/product/I001610.html
OChem	7723	http://www.ocheminc.com/index.php?act=psearch&pid=141H946
Parchem	29099	http://www.parchem.com/chemical-supplier-distributor/Hexetidine-019099.aspx
Sigma-Aldrich	259187_ALDRICH	https://www.sigmaaldrich.com/catalog/product/aldrich/259187?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Sigma-Aldrich	H0325000_SIAL	https://www.sigmaaldrich.com/catalog/product/sial/h0325000?utm_source=pubchem&utm_campaign=pubchem_2017&utm_medium=referral
Smolecule	S529914	http://www.smolecule.com/products/s529914
THE BioTek	bt-270805	https://www.thebiotek.com/product/inhibitors/bt-270805
abcr GmbH	AB180540	http://www.abcr.com/shop/en/AB180540
iChemical	EBD33094	http://www.ichemical.com/products/141-94-6.html?utm_source=PubChem&utm_medium=website&utm_campaign=product%20catalogs
mcule	MCULE-8471986715	https://mcule.com/MCULE-8471986715/

PubMed

Title	Date	PubMed
[Analytical profile of purified hexetidine (author's transl)].	1975	3183
The concomitant development of poly(vinyl chloride)-related biofilm and antimicrobial resistance in relation to ventilator-associated pneumonia.	2001 Oct	11545308
[Hexetidine--an oral antiseptic].	2002	11917691
An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses.	2002 Mar-Apr	12037365
Antimicrobial action of Nitens mouthwash (cetyltrimethylammonium naproxenate) on multiple isolates of pharyngeal microbes: a controlled study against chlorhexidine, benzydamine, hexetidine, amoxicillin, amoxicillin-clavulanate, clarithromycin, and cefaclor.	2002 Sep	12218263
Anti-plaque agents in the prevention of biofilm-associated oral diseases.	2003	12974527
[Efficacy of an antiseptic dialysis of purulent wounds in the dentofacial region with hyvalix].	2007 Jul-Sep	18416174
[Combined local therapy in oropharyngeal diseases].	2008	18454082

Patents

Sample Use Guides

In Vivo Use Guide

mouthwash

Route of Administration: Topical

In Vitro Use Guide

Unknown

Name

Type

Language

HEXETIDINE

Official Name

English

HEXETIDINE [MART.]

Common Name

English

HEXETIDINE [INCI]

Common Name

English

STERISIL

Brand Name

English

HEXETIDINE [EP MONOGRAPH]

Common Name

English

NSC-17764

Code

English

HEXETIDINE [HSDB]

Common Name

English

Hexetidine [WHO-DD]

Common Name

English

hexetidine [INN]

Common Name

English

HEXETIDINE [MI]

Common Name

English

5-AMINO-1,3-BIS(2-ETHYLHEXYL)HEXAHYDRO-5-METHYLPYRIMIDINE

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394