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Details

Stereochemistry MIXED
Molecular Formula C21H45N3
Molecular Weight 339.6029
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HEXETIDINE

SMILES

CCCCC(CC)CN1CC(C)(CN(CC(CC)CCCC)C1)N

InChI

InChIKey=DTOUUUZOYKYHEP-UHFFFAOYSA-N
InChI=1S/C21H45N3/c1-6-10-12-19(8-3)14-23-16-21(5,22)17-24(18-23)15-20(9-4)13-11-7-2/h19-20H,6-18,22H2,1-5H3

HIDE SMILES / InChI

Description
Curator's Comment:: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/11917691

Hexetidine is very safe oral antiseptic with broad antibacterial and antifungal activity in vivo and in vitro. It has local-anesthetics, astringent and deodorant activity. Also, it has very strong antiplac effects. Resistention of microorganisms on hexetidine is short and transient. These characteristics give important therapeutic role in treatment of oral infections. In the UK, hexetidine is the active ingredient in the medicated mouthwash branded Oraldene. Oraldene contains 0.1 g/100 ml of hexetidine. In Germany, hexetidine is used for vaginal antisepsis.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
Oraldene

Approved Use

Unknown
Curative
Oraldene

Approved Use

Unknown
Curative
Oraldene

Approved Use

Unknown
Doses

Doses

DosePopulationAdverse events​
0.1 % 1 times / day multiple, oromucosal
Dose: 0.1 %, 1 times / day
Route: oromucosal
Route: multiple
Dose: 0.1 %, 1 times / day
Sources:
unhealthy, 38.2 years (range: 18–61 years)
n = 46
Health Status: unhealthy
Condition: supragingival plaque | gingivitis
Age Group: 38.2 years (range: 18–61 years)
Sex: M+F
Population Size: 46
Sources:
10 mg 1 times / day multiple, vaginal
Dose: 10 mg, 1 times / day
Route: vaginal
Route: multiple
Dose: 10 mg, 1 times / day
Sources:
unhealthy
n = 100
Health Status: unhealthy
Sex: F
Population Size: 100
Sources:
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
[Analytical profile of purified hexetidine (author's transl)].
1975
[Disturbances of taste from oral disinfectants (author's transl)].
1978 Oct
The erosive effects of some mouthrinses on enamel. A study in situ.
2001 Apr
The concomitant development of poly(vinyl chloride)-related biofilm and antimicrobial resistance in relation to ventilator-associated pneumonia.
2001 Oct
A comparative study in vivo of the therapeutic effect of triclosan, hexetidine and chitosan.
2002
An in vitro oral biofilm model for comparing the efficacy of antimicrobial mouthrinses.
2002 Mar-Apr
Anti-plaque agents in the prevention of biofilm-associated oral diseases.
2003
Antiplaque and antigingivitis effectiveness of a hexetidine mouthwash.
2003 Jul
Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis.
2005 Sep
[Stopangin in the treatment of pharyngeal inflammation].
2006
Fluconazole and/or hexetidine for management of oral candidiasis associated with denture-induced stomatitis.
2006 Jul
[Efficacy of an antiseptic dialysis of purulent wounds in the dentofacial region with hyvalix].
2007 Jul-Sep
[Combined local therapy in oropharyngeal diseases].
2008
Efficacy of vaginal misoprostol before hysteroscopy for cervical priming in patients who have undergone cesarean section and no vaginal deliveries.
2008 Jul-Aug
Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons.
2009 Sep 23
Parotid gland swelling following mouthrinse use.
2010 Nov
The effect of hexetidine mouthwash on the prevention of plaque and gingival inflammation: a systematic review.
2011 Aug
Patents

Sample Use Guides

mouthwash
Route of Administration: Topical
In Vitro Use Guide
Curator's Comment:: all information about in vitro activity in german
Unknown
Name Type Language
HEXETIDINE
EP   HSDB   INCI   INN   MART.   MI   WHO-DD  
INN   INCI  
Official Name English
HEXETIDINE [WHO-DD]
Common Name English
HEXETIDINE [MART.]
Common Name English
HEXETIDINE [INCI]
Common Name English
STERISIL
Brand Name English
HEXETIDINE [EP MONOGRAPH]
Common Name English
NSC-17764
Code English
HEXETIDINE [HSDB]
Common Name English
HEXETIDINE [INN]
Common Name English
HEXETIDINE [MI]
Common Name English
5-AMINO-1,3-BIS(2-ETHYLHEXYL)HEXAHYDRO-5-METHYLPYRIMIDINE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C28394
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
WHO-ATC A01AB12
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
WHO-ATC G01AX16
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
WHO-VATC QA01AB12
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
Code System Code Type Description
MERCK INDEX
M6009
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY Merck Index
MESH
D006590
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
NCI_THESAURUS
C77049
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
RXCUI
5301
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY RxNorm
ECHA (EC/EINECS)
205-513-5
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
CAS
141-94-6
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
WIKIPEDIA
Hexetidine
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
FDA UNII
852A84Y8LS
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
PUBCHEM
3607
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
DRUG CENTRAL
3277
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
EPA CompTox
141-94-6
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
DRUG BANK
DB08958
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
INN
522
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
HSDB
7828
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
EVMPD
SUB08037MIG
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY
ChEMBL
CHEMBL144673
Created by admin on Fri Jun 25 21:11:39 UTC 2021 , Edited by admin on Fri Jun 25 21:11:39 UTC 2021
PRIMARY